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IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis
(2016-10-15)
This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three components, IFN-β, NAg, and Alum, for ...
Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
(2016)
Background: Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote
tumor development and to be a good target for cancer treatment. Most studies to date have used human
mesothelin ...
Proteome quantification of cotton xylem sap suggests the mechanisms of potassiumdeficiency-induced changes in plant resistance to environmental stresses
(2016-02)
Proteomics was employed to investigate the molecular mechanisms of apoplastic response to potassium(K)-deficiency in cotton. Low K (LK) treatment significantly decreased the K and protein contents of xylem sap. Totally, ...
Non-pegmatitic beryl related to Carboniferous granitic magmatism, Velasco Range, Pampean Province, NW Argentina
(2016)
The specialized leuco-monzogranite of the La Chinchilla Stock is a small Carboniferous stock located in the center of the Velasco Range, Pampean Province, La Rioja, Argentina. It is highly evolved and locally F- and ...
Identifying Lesbian, Gay, Bisexual, and Transgender Search Terminology: A Systematic Review of Health Systematic Reviews
(2016-05-24)
Research on the health of lesbian, gay, bisexual, and transgender (LGBT) populations can
provide important information to address existing health inequalities. Finding existing
research in LGBT health can prove challenging ...
Impact of a Revised Curriculum Focusing on Clinical Neurology and Musculoskeletal Care on a Required Fourth-Year Medical Student Physical Medicine and Rehabilitation Clerkship
(2016-11-29)
Background. A Required Fourth-Year Medical Student Physical Medicine and Rehabilitation (PM&R) Clerkship was found to increase students' knowledge of PM&R; however the students' overall rotation evaluations were consistently ...
Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents
(2016-07)
Cancer is the second leading cause of death in the United States with 1.7 million
new cases estimated to be diagnosed in 2016. This disease remains a formidable
clinical challenge and represents a substantial financial ...
Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia
(2016-08-01)
An attractive molecular target for novel anti-cancer therapies is the
phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway which is commonly deregulated in many types of cancer. Nevertheless, ...