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Evolution of plant nucleotide-sugar interconversion enzymes
(2011-11-18)
Nucleotide-diphospho-sugars (NDP-sugars) are the building blocks of diverse polysaccharides and glycoconjugates in all organisms. In plants, 11 families of NDP-sugar interconversion enzymes (NSEs) have been identified, ...
Genome-wide functional analysis of the cotton transcriptome by creating an integrated EST database
(2011-11-08)
A total of 28,432 unique contigs (25,371 in consensus contigs and 3,061 as singletons) were assembled from all 268,786 cotton ESTs currently available. Several in silico approaches [comparative genomics, Blast, Gene Ontology ...
Experimental design and statistical rigor in phylogenomics of horizontal and endosymbiotic gene transfer
(2011-09-16)
A growing number of phylogenomic investigations from diverse eukaryotes are examining conflicts among gene trees as evidence of horizontal gene transfer. If multiple foreign genes from the same eukaryotic lineage are found ...
Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression
(2011-04-06)
Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient passage ...
Executive summary: "Mantle Frontier" workshop
(2011-03)
The workshop on “Reaching the Mantle Frontier: Moho and Beyond” was held at the Broad Branch Road Campus of the Carnegie Institution of Washington on 9–11 September 2010. The workshop attracted seventy-four scientists and ...
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells
(2011-08-30)
Escape from cellular senescence induction is a potent mechanism for chemoresistance. Cellular senescence can be induced in breast cancer cell lines by the removal of estrogen signaling with tamoxifen or by the accumulation ...
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α<inf>2</inf>β <inf>1</inf>in mice
(2011)
OBJECTIVE:
The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through ...
Coronary artery ligation and intramyocardial injection in a murine model of infarction
(2011-06-07)
Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo . With the advent of genetic modifications to the whole organism or the myocardium and an array of biological ...
Diabetic muscle infarction: A rare complication of long-standing and poorly controlled diabetes mellitus
(2011-10-09)
Objective. To report a case of diabetic muscle infarction (DMI), a rare complication of long-standing poorly controlled diabetes mellitus. Methods. We describe a case of a 45-year-old male with an approximately 8-year ...