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Fish oil disrupts B cell plasma membrane lateral organization and immunological synapse formation
(East Carolina University, 2012)
Fish oil has immunosuppressive properties that could provide treatment for numerous inflammatory and autoimmune disorders. The primary bioactive components of fish oil, which are the n-3 polyunsaturated fatty acids (PUFAs) ...
An examination of the functional role of TMEFF2 in prostate cancer and the translational regulatory mechanisms controlling its expression
(East Carolina University, 2012)
Prostate cancer is the most commonly diagnosed cancer in American men and accounts for approximately 11% of cancer-related deaths. Although promising treatment strategies have been developed and are currently being tested ...
Fesselin, a Synaptopodin-like Protein, Stimulates Actin Nucleation and Polymerization
(East Carolina University, 2001-11-27)
Fesselin is a proline-rich actin binding protein that has recently been isolated from smooth muscle [Leinweber, B. D., Fredricksen, R. S., Hoffman, D. R., and Chalovich, J. M. (1999) J. Muscle Res. Cell Motil. 20, 539–545]. ...
The Actin Binding Protein, Fesselin, is a Member of the Synaptopodin Family
(East Carolina University, 2008-07)
Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively
unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and
α-actinin. Fesselin ...
Ca2+ and Ionic Strength Dependencies of S1-ADP Binding to Actin-Tropomyosin-Troponin: Regulatory Implications
(East Carolina University, 2004-09)
Skeletal and cardiac muscle contraction are inhibited by the actin-associated complex of tropomyosin-troponin. Binding of Ca21 to troponin or binding of ATP-free myosin to actin reverses this inhibition. Ca21 and ATP-free ...
Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.
(East Carolina University, 1999-12)
The purpose of this study was to address the paradox of calponin localization with a-actinin and filamin, two proteins with tandem calponin homology (CH) domains, by determining the effect of these proteins on the binding ...
Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
(East Carolina University, 2012)
The human growth hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs). The region encompassing HSI and HSII contains the predominant ...
Effects of Exogenous and Autocrine Growth Hormone (hGH) on Prostate Cancer Cell Function
(East Carolina University, 2012)
Human growth hormone (hGH) is a major product of the anterior pituitary. In addition to its endocrine activities, hGH overexpression in extra-pituitary tissues has been correlated with the oncogenic behavior of these ...