HOW CAN WE REDUCE THE EFFECTS OF ENVIRONMENTAL POLLUTANTS ON THE PLACENTA?

Abstract

Prenatal exposure to endocrine disrupting chemicals can lead to birth defects and adult disease. While it is impossible to avoid pollutant exposure, development of a prenatal supplement that augments natural protective mechanisms would be invaluable. Here, I show that prenatal supplementation with sulforaphane reduces gene changes caused by a model endocrine disrupting chemical. Further the candidate mechanisms of resilience associated with this rescue were identified.