Browsing Internal Medicine by Author "Kukoly, Cynthia A."
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MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
Ways, D. Kirk; Kukoly, Cynthia A.; DeVente, James E.; Hooker, Jerry L.; Bryant, Winifred O.; Posekany, Karla J.; Fletcher, Donald J.; Cook, Paul P.; Parker, Peter J. (East Carolina University, 1995-04)Increased protein kinase C (PKC) activity in malignant breast tissue and positive correlations between PKC activity and expression of a more aggressive phenotype in breast cancer cell lines suggest a role for this signal ... -
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
de Vente, James E.; Kukoly, Cynthia A.; Bryant, Winifred O.; Posekany, Karla J.; Chen, Jianming; Fletcher, Donald J.; Parker, Peter J.; Pettit, George J.; Lozano, Guillermina; Cook, Paul P.; Ways, D. Kirk (East Carolina University, 1995-10)Protein kinase C (PKC) modulates growth, differentiation, and apoptosis in a cell-specific fashion. Overexpression of PKC-a in MCF-7 breast cancer cells (MCF-7-PKC-a cell) leads to expression of a more transformed phenotype. ... -
Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours
Burke, Lillian P.; Kukoly, Cynthia A. (East Carolina University, 2008-02)HMG-CoA Reductase inhibitors (statins) induce apoptosis in acute myeloid leukemia (AML) cells in vitro; however, the concentrations associated with cell death in AML cells are higher than those clinically tolerated during ...