Now showing items 9-20 of 20

  • Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study 

    Gipson, Debbie S.; Selewski, David T.; Massengill, Susan F.; Wickman, Larysa; Messer, Kassandra L.; Herreshoff, Emily; Bowers, Corinna; Ferris, Maria E.; Mahan, John D.; Greenbaum, Larry A.; MacHardy, Jackie; Kapur, Gaurav; Chand, Deepa H.; Goebel, Jens; Barletta, Gina Marie; Geary, Denis; Kershaw, David B.; Pan, Cynthia G.; Gbadegesin, Rasheed; Hidalgo, Guillermo; Lane, Jerome C.; Leiser, Jeffrey D.; Plattner, Brett W.; Song, Peter X.; Thissen, David; Liu, Yang; Gross, Heather E.; DeWalt, Darren A. (2013)
    Background and objectives Nephrotic syndrome (NS) represents a common disease in pediatric nephrology typified by a relapsing and remitting course and characterized by the presence of edema that can significantly affect ...
  • Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis 

    Hoffman, William H.; Passmore, Gregory G.; Hannon, David W.; Talor, Monica V.; Fox, Pam; Brailer, Catherine; Haislip, Dynita; Keel, Cynthia; Harris, Glenn; Rose, Noel R.; Fiordalisi, Irma; Čiháková, Daniela (2013)
    Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and ...
  • LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model 

    Fuh, B.; Sobo, M.; Cen, L.; Josiah, D.; Hutzen, B.; Cisek, K.; Bhasin, D.; Regan, N.; Lin, L.; Chan, C.; Caldas, H.; DeAngelis, S.; Li, C.; Li, P-K.; Lin, J. (East Carolina University, 2009-01-13)
    Persistent activation of the signal transducer and activator of transcription 3 (STAT3) signalling has been linked to oncogenesis and the development of chemotherapy resistance in glioblastoma and other cancers. Inhibition ...
  • Off-label Utilization of Antihypertensive Medications in Children 

    Yoon, Esther Y.; Dombkowski, Kevin J.; Rocchini, Albert; Lin, Jen-Jar; Davis, Matthew M. (East Carolina University, 2007-07)
    Objective— To examine off-label utilization and costs of antihypertensive drugs in children using a national sample of prescription claims. Design— Cross-sectional study. Setting— 2002 Medstat MarketScan Database, a national ...
  • Patterns of Distress in African American Mothers of Preterm Infants 

    Holditch-Davis, Diane; Miles, Margaret Shandor; Weaver, Mark A.; Black, Beth; Beeber, Linda; Thoyre, Suzanne; Engelke, Stephen C. (East Carolina University, 2009-06)
    Objective: To examine inter-relationships among stress due to infant appearance and behavior in the NICU, parental role alteration stress in the NICU, depressive symptoms, state anxiety, posttraumatic stress symptoms, and ...
  • Prenatal diagnosis of a giant intracranial teratoma associated with pulmonary hypoplasia. 

    Weyerts, Leah K.; Catanzarite, Val; Jones, Marilyn C.; Mendoza, Arturo (East Carolina University, 1993-10)
    We present a case in which an intracranial tumour replacing all intracranial contents was diagnosed by sonography at 31 weeks' gestation. The patient was delivered by caesarean section and died shortly after delivery. At ...
  • Promising insights into the health related quality of life for children with severe obesity 

    Selewski, David T.; Collier, David N.; MacHardy, Jackie; Gross, Heather E.; Pickens, Edward M.; Cooper, Alan W.; Bullock, Selam; Earls, Marian F.; Pratt, Keeley J.; Scanlon, Kelli; McNeill, Jonathan D.; Messer, Kassandra L.; Lu, Yee; Thissen, David; DeWalt, Darren A.; Gipson, Debbie S. (2013)
    Background Childhood obesity is a growing health concern known to adversely affect quality of life in children and adolescents. The Patient Reported Outcomes Measurement Information System (PROMIS) pediatric measures ...
  • Quality of life and BMI changes in youth participating in an integrated pediatric obesity treatment program 

    Pratt, Keeley J.; Lazorick, Suzanne; Lamson, Angela L.; Ivanescu, Andrada; Collier, David N. (2013)
    Background Changes in Quality of Life (QOL) measures over time with treatment of obesity have not previously been described for youth. We describe the changes from baseline through two follow up visits in youth QOL (assessed ...
  • Response to Kuhse 

    Perkin, R. M.; Resnik, D. B. (East Carolina University, 2002-08)
    In this short paper, we respond to critics of our original paper, The agony of agonal respiration: is the last gasp necessary?. A common thread in both Hawryluckâ s and Kuhseâ s responses is the difficulties encountered ...
  • Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease 

    Offenbacher, Steven; Beck, James D.; Moss, Kevin; Mendoza, Luisito; Paquette, David W.; Barrow, David A.; Couper, David J.; Steward, Dawn D.; Falkner, Karen L.; Graham, Susan P.; Grossi, Sara; Gunsolley, John C.; Madden, Theresa; Maupome, Gerardo; Trevisan, Maurizio; Van Dyke, Thomas E.; Genco, Robert J. (East Carolina University, 2009-02)
    Background- In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. ...
  • Sugar-Sweetened Beverage Consumption and Food Insecurity in Pediatric Patients with Obesity 

    Bostick, Kimberly Paige (2015-04-30)
    Consumption of sugar sweetened beverages and food insecurity are both thought to contribute to the development of obesity. However, little is known about the quantity and quality of sugar-sweetened beverages consumed, the ...
  • Traces of embryogenesis are the same in monozygotic and dizygotic twins: not compatible with double ovulation 

    Boklage, Charles E. (East Carolina University, 2009-06)
    Common knowledge of over a century has it that monozygotic and dizygotic twinning events occur by unrelated mechanisms: monozygotic twinning ‘splits’ embryos, producing anomalously re-arranged embryogenic asymmetries; ...