Browsing Pharmacology and Toxicology by Title
Now showing items 89-108 of 114
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Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
(2015-04)Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ... -
OPPOSING PERSISTENT BEHAVIORAL EFFECTS OF PHYTO- AND ENDOCANNABINOIDS FOLLOWING CHRONIC DEVELOPMENTAL, BUT NOT ADULT, TREATMENTS
(East Carolina University, 2019-04-23)The rate of adolescent Cannabis abuse is increasing for recreational purposes and it is thought to be linked to a range of developmental and social problems. Many studies have demonstrated effects of early Cannabis exposure ... -
Oxytocin Modulation of Zebra Finch Vocal Development
(East Carolina University, 2010)Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ... -
OZONE-INDUCED ALTERATIONS IN MACROPHAGE FUNCTION AND THE PROTECTIVE ROLE OF SR-BI
(East Carolina University, 2020-06-22)Ozone (O3), a criteria air pollutant, is the primary component of photochemical smog. Currently, over 140 million people in the United States are exposed to levels of O3 deemed unhealthy by the Environmental Protection ... -
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ... -
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
(East Carolina University, 2006-12-29)Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that ... -
Prohibitin: A novel regulator of inflammatory cell dynamics
(East Carolina University, 2020-02-04)Inflammation is a complex mechanism primarily driven by the immune system to eradicate pathogens/foreign substances and restore tissue homeostasis. Despite the beneficial effects that inflammation employs, signaling can ... -
Purification and Partial Characterization of Relaxin and Relaxin Precursors from the Hamster Placenta
(East Carolina University, 1993-07)Previous immunological studies have indicated that the molecular structure of hamster relaxin is quite different from that of porcine relaxin. In the present study, hamster relaxin was purified from placentas and ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with it
(2002-07-30)Satiety inducing composition comprises Neuropeptide Y analogues which are effective for inducing satiety and for treating diseases and conditions associated with a lacking of, or having lowered, satiety. -
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
(East Carolina University, 2008-11-03)The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ... -
Smoking and dietary inadequacy among Inuvialuit women of child bearing age in the Northwest Territories, Canada
(2013)Objective The prevalence of smoking in Aboriginal Canadians is higher than non-Aboriginal Canadians, a behavior that also tends to alter dietary patterns. Compared with the general Canadian population, maternal smoking ...