Browsing Pharmacology and Toxicology by Author "Chen, Yan-Hua"
-
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Zeng, Yan; Abdallah, Agustin; Lu, Jian-Ping; Wang, Tao; Chen, Yan-Hua; Terrian, David M.; Kim, Kwonseop; Lu, Qun (East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ... -
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
Lu, Qun; Zhang, Jiao; Allison, Ron R.; Gay, Hiram A.; Yang, Wan-Xi; Bhowmick, Neil; Frelix, Gloria; Shapell, Scott; Chen, Yan-Hua (East Carolina University, 2009-03-01)BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
Wang, Tao; Chen, Yan-Hua; Hong, Heng; Zeng, Yan; Zhang, Jiao; Lu, Jian-Ping; Jeansonne, Beverly; Lu, Qun (East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ... -
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
Chen, Yan-Hua; Lu, Qun; Goodenough, Daniel A.; Jeansonne, Beverly (East Carolina University, 2002-04)Occludin is an integral membrane protein that is tyrosine phosphorylated when localized at tight junctions. When Ca2 was depleted from the culture medium, occludin tyrosine phosphorylation was diminished from Madin-Darby ...