Search
Now showing items 21-30 of 58
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
(East Carolina University, 2017-07-25)
The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ...
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
(East Carolina University, 2018-07-17)
Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ...
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)
Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ...