Browsing by Author "Hickner, Robert C."
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No-dependent regulation of muscle blood flow in fibromyalgia patients and healthy adults
McIver, Kerry Leigh -
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
Fisher-Wellman, Kelsey H.; Mattox, Taylor A.; Thayne, Kathleen; Katunga, Lalage Adalaide; La Favor, Justin D.; Neufer, P. Darrell; Hickner, Robert C.; Wingard, Christopher J.; Anderson, Ethan (2013)Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ... -
Obese Children Have a Lower Lipolytic Response to an Acute Bout of Exercise When Compared to Lean
Geyer, Gabriel Hardy (East Carolina University, 2010)Over 17% of American children are obese. These are epidemic proportions considering the associated risk of heart disease and Type 2 diabetes. Excess fat is caused from an imbalance in energy stored versus energy expended. ... -
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
Kwak, Hyo-Bum; Woodlief, Tracey L.; Green, Thomas D.; Cox, Julie H.; Hickner, Robert C.; Neufer, P. Darrell; Cortright, Ronald N. (2019-03-31)In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ... -
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle
Huang, Tai-Yu; Zheng, Donghai; Hickner, Robert C.; Brault, Jeffrey J.; Cortright, Ronald N. (2020-04-21)Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment ... -
Prevalence of coronary heart disease risk factors in physical education students
Moreira, Osvaldo Costa; Matos, Dihogo Gama de; Hickner, Robert C.; Oliveira, Renata Aparecida Rodrigues de; Aidar, Felipe José; Oliveira, Cláudia Eliza Patrocínio de; Rodríguez-Gázquez, Maria de los Ángeles (2015)Abstract To establish the prevalence of coronary risk in physical education students, and compare risk between the genders and the years of course. We evaluated 246 physical education students using RISKO questionnaire to ... -
Prevalence of coronary heart disease risk factors in physical education students
Moreira, Osvaldo Costa; Oliveira, Cláudia Eliza Patrocínio de; Matos, Dihogo Gama de; Hickner, Robert C.; Oliveira, Renata Aparecida Rodrigues de; Aidar, Felipe José; Rodríguez-Gázquez, Maria de los Ángeles (2015)Abstract To establish the prevalence of coronary risk in physical education students, and compare risk between the genders and the years of course. We evaluated 246 physical education students using RISKO questionnaire to ... -
The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
Gavin, Kathleen M. (East Carolina University, 2012)Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ... -
REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN
Raymer, Dustin K. (East Carolina University, 2012)African-American women (AAW) are twice as likely to be obese as Caucasian women (CW); however, previous in-vitro studies have shown that AAW have higher densities of beta-adrenergic receptors (B-AR) in the subcutaneous ... -
Regulation of Lipolysis By Perilipin : influence of Obesity and Exercise Training
Johnson, Emily Ann (East Carolina University, 2010)Obesity is the result of excess energy storage due to an imbalance between energy storage and energy utilization. Excess energy is stored as triacylglycerol (TAG) in adipose tissue in various regions throughout the body. ... -
Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium
Benjamin, Ramsis K.; Hochberg, Fred H.; Fox, Elizabeth; Bungay, Peter M.; Elmquist, William F.; Stewart, Clinton F.; Gallo, James M.; Collins, Jerry M.; Pelletier, Robert P.; de Groot, John F.; Hickner, Robert C.; Cavus, Idil; Grossman, Stuart A.; Colvin, O. Michael (East Carolina University, 2004-01)In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily ... -
Training and Endothelial Function In Upper and Lower Limbs
Bires, Anna Kate (East Carolina University, 2013)Cardiovascular disease (CVD) begins with damage to the endothelium, the inner lining of the blood vessels. Endothelial damage occurs as early as childhood and is associated with risk factors such as obesity, hypertension, ...