Browsing by Subject "Diabetes"
Now showing items 21-36 of 36
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Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
(East Carolina University, 2008-12)Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ... -
miRDiabetes : A microRNA-Diabetes Association Database Constructed With Data Mining on Literature
(East Carolina University, 2014)MicroRNAs (miRNAs) are a growing class of non-coding RNAs that regulate gene expression by translational repression. A role for miRNA in diabetes was first established in 2004 and research in miRNA-diabetes association has ... -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
(2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ... -
Oral health, diabetes, and inflammation: Effects of oral hygiene behavior
(Elsevier, 2021-11-29)The aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association. Data were from the 2009–2010 National ... -
PAIN SUPPORT FROM FAMILY AND PROVIDERS IN THE DIABETIC AMPUTEE: A LIVED EXPERIENCE
(East Carolina University, 2018-05-03)Chronic pain after lower extremity amputation surgery has been reported in up to 80% of patients. Amputations, which are among the most debilitating chronic complication of diabetes have a variety of consequences including ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
Patients with Type 2 Diabetes: New Technologies and Social Media
(2015-12-02)Patients with Type 2 Diabetes Mellitus (DMT2) often visit with primary care providers for quarterly checkups, as suggested by the American Diabetes Association (ADA) standards of care. Following these visits, which usually ... -
The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
(East Carolina University, 2011)Diabetic patients are more susceptible to ischemia/reperfusion injury and cardiac dysfunction likely due alterations in mitochondrial calcium handling. The purpose of this work was to determine if redox-dependent changes ... -
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ... -
The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume
(2016-10-26)Purpose: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a ... -
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
(East Carolina University, 2012)Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ... -
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ... -
Utilizing Brain Activity to Non-Invasively Predict Blood Glucose Levels
(East Carolina University, 2016-12-16)Diabetes Mellitus is a chronic condition that must be routinely self-monitored to prevent life threatening complications, diabetic coma, and to mitigate long-term complications, such as neuropathy and kidney failure. Despite ... -
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.
(East Carolina University, 1995-09)OBJECTIVE: This report documents that the gastric bypass operation provides long-term control for obesity and diabetes. SUMMARY BACKGROUND DATA: Obesity and diabetes, both notoriously resistant to medical therapy, continue ...