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Now showing items 2286-2305 of 10629
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Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as [alpha]-synucleinopathies, most notably dementias and Parkinson's Disease (PD), are characterized by neuronal aggregation and accumulation of [alpha]-synuclein ([alpha]-syn) ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that ... -
Defining the Role of the C-Terminal Region of Troponin T by Analysis of a Series of Truncation Mutants
(East Carolina University, 2016-07-21)Familial hypertrophic cardiomyopathy and other cardiovascular diseases result from mutations of any of the contractile proteins. Mutations within the actin binding regulatory complex of proteins, including tropomyosin (Tm) ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)Sea-level fluctuations throughout the late Quaternary Period are recorded in the shallow stratigraphy and modern geomorphology of coastal North Carolina. In the Albemarle Sound region, four distinct Pleistocene sea-level ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)We need to replace the abstract. -
The Definition of the Work Entity for Pieces of Recorded Sound
(2015-10)The traditional work-instance model differentiates between the intellectual content of a work and the semantic content of its material instantiations. Most scholarship on musical works has concentrated on classical music ... -
Defragmentation of in-vitro fertilization blastocyst stage embryos leading to rescued blastocyst expansion and clinical pregnancy
(2020-10-19)Embryo fragmentation, or extrusion of cell fragments, is a naturally occurring phenomenon that may be associated with impaired embryo development, failed implantation and decreased pregnancy rates. Previous studies have ... -
Dehiscence and embolization of CorMatrix tricuspid valve replacement in the setting of infective endocarditis: a case report
(2018-01-31)Background: Due to increased morbidity and mortality, prosthetic valve infective endocarditis (IE) with dehiscence requires urgent intervention. Early identification and therapy may prevent embolization. Case summary: A ... -
DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis
(East Carolina University, 2010-04-15)Public concerns on phthalates distributions in the environment have been increasing since they can cause liver cancer, structural abnormalities and reduce sperm counts in male reproductive system. However, few data are ... -
Delayed Self-Fertilization in Triodanis perfoliata
(2014)Self-fertilization is a reproductive technique that allows a plant to produce offspring even when pollinators may be scarce. Utilizing the process of delayed selfing, a species is with the benefits of both cross-pollination ... -
Deletion of BmoR affects the expression of genes related to thiol/disulfide balance in Bacteroides fragilis
(2018-09-26)Bacteroides fragilis, an opportunistic pathogen and commensal bacterium in the gut, is one the most aerotolerant species among strict anaerobes. However, the mechanisms that control gene regulation in response to oxidative ... -
Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ... -
Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice
(2015)Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
(2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
(East Carolina University, 2008-04-25)In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ...