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Now showing items 8148-8167 of 10629
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The role of fishing material culture in communities’ sense of place as an added-value in management of coastal areas
(2016)Fishing communities in many places around the world are facing significant challenges due to new policies and environmental developments. While it is imperative to ensure sustainability of natural resources, many policies ... -
The Role of GSK-3[beta] in MCF-7 Breast Cancer Cell Signaling and Drug Resistance
(East Carolina University, 2011)Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of critical cellular processes. This versatile protein is involved in numerous signaling pathways that influence metabolism, ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
The role of lexical and semantic access efficiency in predicting reading fluency in second and third grade children.
(East Carolina University, 2011)The present study investigated the role of lexical and semantic access efficiency in predicting reading fluency levels in 32 second and third grade students (16 second grade/16 third grade). In a series of lexical and ... -
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ... -
Role of Macrophage Polarization and Apolipoprotein E in Granuloma Resolution
(East Carolina University, 2021-07-06)Sarcoidosis is a chronic disease characterized by the development and accumulation of granulomas. Through multiwall carbon nanotube (MWCNT) instillation of C57 Bl/6 (wild-type) mice, we have established a murine model that ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
The Role of Mitochondrial Biogenesis in Human Mesenchymal Stem Cell Differentiation and Acquisition of a Cardiac Phenotype
(East Carolina University, 2013)Introduction: With an increased understanding of myocardial infarction, human mesenchymal stem cell (hMSC) transplantation therapies have shown promising results as a possible treatment for heart failure. However, little ... -
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic neurosecretory centers. nNOS gene deletion ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
The role of peroxisome proliferator-activated receptor-gamma in surfactant catabolism in the alveolar macrophage
(East Carolina University, 2009)Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by surfactant accumulation in the alveolar spaces and alveolar macrophages. Although PAP is rare, surfactant abnormalities occur in many lung diseases ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013-01-23)Background Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
THE ROLE OF RACE AND GENDER IN THE MENTORING EXPERIENCES AND CAREER SUCCESS OF AFRICAN AMERICAN FEMALE SENIOR EXECUTIVE ADMINISTRATORS IN HIGHER EDUCATION
(East Carolina University, 2009)From 1995 to 2005 education doctoral degrees conferred to African American females increased by 92%, however the increase in availability among this population for higher education administrator positions has not kept pace ... -
The role of relationship phase and stalking myths on perception of stalking
(2015-05-29)Intimate partner violence (IPV) myths draw the following conclusions: the victim is blamed, the perpetrator is exonerated, and the situation is minimized (Lonsway, Cortina, & Magley, 2008; Payne, Lonsway, & Fitzgerald, ... -
The Role of Retinoic Acid (RA) in Spermatogonial Differentiation
(2016)Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the generation of functional spermatozoa. These processes are ... -
THE ROLE OF ROYAL POWER IN THE FORMATION OF AN ANGLO-SAXON STATE, CIRCA 400-900 AD
(East Carolina University, 2012)This thesis explores the formation of a state in Anglo-Saxon England from the period of Roman withdrawal from Britain in the early fifth century to the tenth century. It argues that the key factor in the development of the ...