Browsing by Title
Now showing items 4736-4755 of 5450
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Targeted therapy for hepatocellular carcinoma: Novel agents on the horizon
(2012-03-31)Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ... -
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ... -
TARGETING ENZYMES OF SPHINGOLIPID METABOLISM IN TREATMENT OF COLORECTAL CANCER
(East Carolina University, 2019-05-03)Alterations in sphingolipid (SL) metabolism can contribute to cancer progression as well as chemotherapy resistance. Thus, the enzymes of SL metabolism are exploitable targets for the development of novel therapeutics. ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
(East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ... -
Targeting prostate cancer based on signal transduction and cell cycle pathways
(East Carolina University, 2008-06-15)Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, ... -
Targeting Psychological Flexibility in Youth to Enhance Health-Related Behaviors
(East Carolina University, 2019-07-22)Background: Adolescents are uniquely vulnerable to a wide range of psychological issues and often, concerns inadequately addressed. When addressed, mental health concerns are commonly handled in schools, which are uniquely ... -
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
(East Carolina University, 2009-01)Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological properties have been elucidated, including their distinct replicative properties, cell surface phenotypes, their ... -
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ... -
Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance
(East Carolina University, 2007) -
Task Specific Effects of Unilateral Eccentric and Concentric Exercise on Spinal Excitability of the Contralateral Homologous Plantar Flexors.
(East Carolina University, 2011)It is well established that resistance training increases the size and strength of the trained muscles. It is also known that unilateral muscle contractions can produce strength gains in the non-exercised contralateral ... -
A Taste of Culture : Perceptions About American Fast Food in China
(East Carolina University, 2012)This exploratory study examined perceptions about American fast food among urban, Beijing residents to explore three major objectives; perceptions about taste preferences and nutrition value, the eating relationships of ... -
Teach, Assess, and Redesign: Creating a Framework of Universal Design for Students with Learning Disabilties
(2013-04-12)At the main library of a public, four year university, we are collaborating with an innovative campus program to improve our information literacy services for students with multiple learning disabilities. The poster session ... -
TEACHER AS RESEARCHER: A CASE STUDY ON MULTIMODAL COMMUNICATION INTERVENTION IN THE SPECIAL EDUCATION CLASSROOM
(2014)Functional communication has always been a challenge for individuals with severe intellectual disabilities and speech and language impairments, yet it is one of the most important aspects of our daily life as humans. It ... -
TEACHER EVALUATION IN NORTH CAROLINA : TEACHER PERCEPTIONS DURING A TIME OF CHANGE
(East Carolina University, 2011)Teacher evaluation has the potential to lead to improved instruction and professional growth, but, in practice, this potential is often unrealized. North Carolina has revised its teacher evaluation process to include many ... -
TEACHER FACTORS RELATED TO ACCEPTABILITY AND ADOPTION OF GROUP CONTINGENCY INTERVENTIONS FOR DISRUPTIVE BEHAVIOR
(East Carolina University, 2016-12-15)Disruptive behavior is a frequent problem in many American classrooms, especially in schools with large populations of low income students. Nevertheless, many teachers do not use evidence based behavior management strategies. ... -
Teacher Implemented Pivotal Response Training To Improve Communication In Children With Autism Spectrum Disorders
(East Carolina University, 2011)The primary purpose of this current investigation was to determine if a variation of Pivotal Response Training (PRT) can be effectively implemented by a preschool autism teacher in a classroom setting. The secondary purpose ... -
TEACHER LEADERSHIP PRACTICES IN SUCCESSFUL ELEMENTARY SCHOOLS : A STUDY OF THE IDENTIFICATION, DEVELOPMENT, AND UTILIZATION OF TEACHERS AS LEADERS IN CONSISTENTLY HIGH PERFORMING ELEMENTARY SCHOOLS IN EASTERN NORTH CAROLINA
(East Carolina University, 2014)This dissertation examines the identification, development, and utilization of teachers as leaders in thirteen high performing elementary schools across nine districts in eastern North Carolina. Survey data on these schools ... -
TEACHER PREPARATION COST STUDY : A COMPARATIVE ANALYSIS OF UNC SYSTEM-LEVEL FINANCIAL INPUTS AGAINST CAMPUS-LEVEL PRODUCTIVITY OUTPUTS
(East Carolina University, 2009)The University of North Carolina General Administration has required all constituent institutions with teacher education programs to expand their productivity goals to meet the state's teacher workforce needs. This study ... -
TEACHER QUALITY FACTORS MEDIATING ACHIEVEMENT IN HIGH POVERTY SCHOOLS
(East Carolina University, 2011)The impact of poverty on student achievement was thoroughly researched. Researchers have determined that poverty has a direct negative impact on student achievement. This study analyzed four aspects of teacher quality ... -
Teachers Use Of Own Languages (TUOOLS) : Exploring the Use of African American Rhetorical Strategies in the Composition Classroom
(East Carolina University, 2014)This thesis explores how different African American Rhetorical Strategies are used by African American teachers in a first year college composition classroom. This thesis shows how these different strategies present in ...