Browsing by Author "Alfhili, Mohammad A."
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Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
Lee, Myon Hee; Park, Youngyong; O’Rourke, Samuel; Alfhili, Mohammad A. (2020-01-24) -
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
Park, Youngyong; O’Rourke, Samuel; Taki, Faten A.; Alfhili, Mohammad A.; Hee Lee, Myon (2020-01-24)PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation. Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by interacting with PUF binding element (PBE) in the 30 untranslated ... -
Non-Ionic Surfactants Antagonize Toxicity of Potential Phenolic Endocrine-Disrupting Chemicals, Including Triclosan in Caenorhabditis elegans
Lee, Myon Hee; Alfhili, Mohammad A. (2018-12-31) -
The Soma-Germline Communication: Implications for Somatic and Reproductive Aging
Gaddy, Matthew A.; Kuang, Swana; Alfhili, Mohammad A.; Lee, Myon Hee (2021-05-31) -
Subunits of the DNA Oolymerase Alpha-Primase Complex Promote Notch-Mediated Proliferation with Discrete and Shared Functions in C. elegans Germline
Lee, Myon Hee; Yoon, Dong Suk; Cha, Dong Seok; Alfhili, Mohammad A.; Keiper, Brett D. (2018-05-28) -
THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
Alfhili, Mohammad A. (East Carolina University, 2019-05-07)Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ... -
Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells
Yoon, Dong Suk; Choi, Yoorim; Cha, Dong Seok; Zhang, Peng; Choi, Seong Mi; Alfhili, Mohammad A.; Polli, Joseph Ryan; Pendergrass, DeQwon; Taki, Faten A.; Kapalavavi, Brahmam; Pan, Xiaoping; Zhang, Baohong; Blackwell, T. Keith; Lee, Jin Woo; Lee, Myon-Hee (2017-10-03)Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity ... -
Triclosan: An Update on Biochemical and Molecular Mechanisms
Alfhili, Mohammad A.; Lee, Myon-Hee (2019-05-02)Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical ...