Browsing by Author "Lee, Myon-Hee"
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Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in
Seo, Hyun Won; Cheon, Se-Myeong; Lee, Myon-Hee; Kim, Hong Jun; Jeon, Hoon; Cha, Dong Seok (2015)Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance ... -
Genetic and Chemical Effects on Somatic and Germline Aging
Lee, Myon-Hee; Luo, Huai-Rong; Han Bae, Soo; San-Miguel, Adriana (2020-01-04) -
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
Datla, Udaya Sree (East Carolina University, 2013)The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ... -
Genetic control of cell fate specification in Caenorhabditis elegans germline.
Mamillapalli, Srivalli Swathi (East Carolina University, 2015)The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development ... -
Investigating the Effects of Sodium Benzoate on Fat Deposition and Pharyngeal Pumping and Related Genetic Mechanism in Caenorhabditis elegans
Vang, Jerry Xai (East Carolina University, 2022-07-18)Sodium benzoate is a widely used food preservative common in many household products due to its antibacterial and antifungal activities. However, many of its side effects other than as a preservative has been under research ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
Kobet, Robert A.; Pan, Xiaoping; Zhang, Baohong; Pak, Stephen C.; Asch, Adam S.; Lee, Myon-Hee (2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ... -
Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs
Taki, Faten A.; Pan, Xiaoping; Lee, Myon-Hee; Zhang, Baohong (2014-12-17)Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
Park, Youngyong (East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program
Lee, Myon-Hee; Kim, Kyung Won; Morgan, Clinton T.; Morgan, Dyan E.; Kimble, Judith (2011-05-12)FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. Importantly, FOG-3 activity must be maintained for the continued production of sperm that ... -
PUF-8 and MPK-1: Genetic and Chemical Control of Spermatocyte Dedifferentiation in Caenorhabditis elegans
Gaddy, Matthew A. (East Carolina University, 2021-05-03)Stem cells face a number of major fate decision during their development: the decision to self-renew or differentiate, and then whether to remain differentiated or dedifferentiate, as occurs in some oncogenesis. A regulatory ... -
A simple and rapid method for combining fluorescent in situ RNA hybridization (FISH) and immunofluorescence in the C. elegans germline
Yoon, Dong Suk; Pendergrass, DeQwon L.; Lee, Myon-Hee (2016-05-06)Imaging of RNAs and proteins in specific tissues has opened ample avenues to understand gene expression during development. Recently, a fluorescent in situ RNA hybridization (FISH) method has been developed to analyze the ... -
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans
Cheon, Se-Myeong; Jang, Insoo; Lee, Myon-Hee; Kim, Dae Keun; Jeon, Hoon; Cha, Dong Seok (2017-01)Context: The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neuro- logical disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy of S. ... -
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification
Lee, Myon-Hee; Mamillapalli, Srivalli Swathi; Keiper, Brett D.; Cha, Dong Seok (2016-02)Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. ... -
THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
Alfhili, Mohammad A. (East Carolina University, 2019-05-07)Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ... -
Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells
Yoon, Dong Suk; Choi, Yoorim; Cha, Dong Seok; Zhang, Peng; Choi, Seong Mi; Alfhili, Mohammad A.; Polli, Joseph Ryan; Pendergrass, DeQwon; Taki, Faten A.; Kapalavavi, Brahmam; Pan, Xiaoping; Zhang, Baohong; Blackwell, T. Keith; Lee, Jin Woo; Lee, Myon-Hee (2017-10-03)Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity ... -
Triclosan: An Update on Biochemical and Molecular Mechanisms
Alfhili, Mohammad A.; Lee, Myon-Hee (2019-05-02)Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical ...