Browsing by Author "Tapscott, Edward B."
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Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
Dolan, Patricia L.; Tapscott, Edward B.; Dorton, Peter J.; Dohm, G. Lynis (East Carolina University, 1993-01-15)Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine if contraction-stimulated ... -
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. Lynis; Tapscott, Edward B.; Pories, Walter J.; Dabbs, David J.; Flickinger, Edward G.; Meelheim, Diane; Fushiki, Tohru; Atkinson, Samuel M.; Elton, Charles W.; Caro, Jose F. (East Carolina University, 1988-08)We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ... -
Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.
Kern, Marialice; Wells, James A.; Stephens, Jacqueline M.; Elton, Charles W.; Friedman, Jacob E.; Tapscott, Edward B.; Pekala, Phillip H.; Dohm, G. Lynis (East Carolina University, 1990-09-01)Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glutl), which differ in both ... -
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis (East Carolina University, 2008-12)Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ... -
Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.
Friedman, Jacob E.; Dohm, G. Lynis; Leggett-Frazier, Nancy; Elton, Charles W.; Tapscott, Edward B.; Pories, Walter J.; Caro, Jose F. (East Carolina University, 1992-02)A major defect contributing to impaired insulin action in human obesity is reduced glucose transport activity in skeletal muscle. This study was designed to determine whether the improvement in whole body glucose disposal ... -
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor.
Burguera, Bartolome; Elton, Charles W.; Tapscott, Edward B.; Pories, Walter J.; Dimarchi, Richard; Sakano, Katsu-ichi; Dohm, G. Lynis (East Carolina University, 1994-06-15)Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated, especially in skeletal ...