Browsing Physiology by Title
Now showing items 114-133 of 151
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Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results.
(East Carolina University, 2001-10)L-Arginine may be a conditionally essential amino acid in children and adolescents with sickle cell disease, particularly as required substrate in the arginine-nitric oxide pathway for endogenous nitrovasodilation and ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
(2012-02)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ... -
Physiologic Determinants of Ischemic Skeletal Muscle Pathophysiology
(East Carolina University, 2018-11-29)Lower limb peripheral arterial occlusive disease (PAD) has major impacts on patient quality of life and, in its most severe form, carries a significant risk of mortality. The canonical approach to PAD research has been ... -
Precision Medicine for Heart Failure: Lessons from Oncology
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Predifferentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice
(East Carolina University, 2006)Embryonic stem (ES) cells have been investigated in repair of the CNS following neuronal injury and disease; however, the efficacy of these cells in treatment of postinjury pain is far from clear. In this study, we evaluated ... -
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic neurosecretory centers. nNOS gene deletion ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
(East Carolina University, 2012)microRNAs (miRNAs) are small (21-23 nucleotides) single-stranded RNAs that play important roles in post-transcriptional regulation of gene expression. The binding of miRNA to its specific target mRNAs at 3' UTR causes ...