Browsing Dissertations and Theses by Title
Now showing items 2882-2901 of 4831
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NORTH CAROLINA’S BLACK PATRIOTS OF THE AMERICAN REVOLUTION
(East Carolina University, 2020-06-22)This thesis explores the service of an estimated 468 black men who fought for the American cause during the Revolutionary War. Specifically, it examines those who resided in North Carolina or fought under the forces of ... -
North Carolinians and Amendment One: Religious Participation and Individual Voting Practices
(East Carolina University, 2017-12-14)In 2012, North Carolina residents passed the Amendment One Same-Sex Marriage Ban, which made same-sex marriage illegal at the state constitution level. The goal of this study is to use an integrated sociological perspective ... -
Not Just For Kids : The Impact of Bullying on Academic and Job Performance
(East Carolina University, 2013)Bullying is a sensitive topic of discussion that has recently gained momentum in literature and research. Although the consequences of bullying may be varied, the present study sought to identify specific academic and ... -
Notch 3 Affects Chemoresistance in Colorectal Cancer via DNA Base Excision Repair Enzymes
(East Carolina University, 2017-07-28)Approximately 1.2 million cases of colorectal cancer (CRC) arise each year, and 40-50% of CRC patients will reach metastasis. The Notch pathway is known to be dysregulated in CRC, and its relationship with DNA repair ... -
Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells via Effects on DNA Repair Proteins
(East Carolina University, 2016-07-25)Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment ... -
Notched Acoustic Stimulus and Tinnitus: A Treatment Intervention Using a Randomization Test Approach
(East Carolina University, 2014)Musical training has considerable effects on human brain plasticity and music listening has been investigated as a means of treating tinnitus. In a laboratory setting, tailor-made notched music has been shown to reduce ... -
Note taking skills using the LiveScribe pen: implications for college students diagnosed with learning disabilities
(East Carolina University, 2014)The purpose of this study was to examine whether the use of strategic note-taking with the LiveScribe© pen increased the quantity of idea units, quality of notes written down, and retention of information provided for ... -
NOVEL BIOLOGICS PROMOTE STABLE EXPANSION OF REGULATORY CD25HIGH FOXP3+ T LYMPHOCYTES AS A MEANS FOR AN ADOPTIVE CELL-BASED IMMUNOTHERAPY
(East Carolina University, 2021-06-18)Autoimmune disease arises when a breakdown in immunological self-tolerance causes self-reactive tissue destruction. In Multiple Sclerosis (MS), myelin reactive CD4+ T cells initiate an immune attack on the myelin sheath ... -
Novel diagnostic and analytical applications of benchtop time-domain NMR.
(East Carolina University, 2015)High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
(East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
(East Carolina University, 2014)Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ... -
Novel Nano-Based Antibacterial Therapeutic Against Hospital Acquired Infection
(East Carolina University, 2022-07-19)Rising nosocomial infections, also called hospital-acquired infections (HAIs), are of imminent public health concern as common antibiotics, such as ampicillin and kanamycin, are becoming less effective against bacterial ... -
Novel Nano-Based Antibacterial Therapeutic Against Hospital Acquired Infection
(East Carolina University, 2022-07-19)Rising nosocomial infections, also called hospital-acquired infections (HAIs), are of imminent public health concern as common antibiotics, such as ampicillin and kanamycin, are becoming less effective against bacterial ... -
NOVEL NUCLEOLAR LOCALIZATION OF SYNAPTOPODIN-2 ISOFORM IN PROLIFERATING HT-29 CELLS
(East Carolina University, 2021-07-13)Members of the Synaptopodin family regulate [alpha]-actinin and actin-bundling activity, in an isoform specific manner (Asunama et al., 2005). The ability to affect actin polymerization and bundling highlights the critical ... -
NOVEL ROLE OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-1 ENCODED PROTEIN HBZ IN VIRAL TRANSMISSION THROUGH CELL-TO-CELL CONTACT
(East Carolina University, 2017-04-28)The complex retrovirus Human T cell leukemia virus type I (HTLV-1) is the etiologic agent of several diseases, including Adult T cell leukemia (ATL), a fatal hematological malignancy that affects mainly CD4+ T-cells. Freshly ... -
Novel roles for ecdysone receptor in the Drosophila germline
(East Carolina University, 2022-07-01)Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for ... -
Novel roles for ecdysone receptor in the Drosophila germline
(East Carolina University, 2022-07-01)Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for ...