Browsing Dissertations and Theses by Title
Now showing items 3482-3501 of 4831
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RNA polymerase II CTD Evolutionary Diversity and Associated Protein Identification in Green and Red Algae
(East Carolina University, 2014)In model eukaryotes, the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II is composed of tandemly repeated heptads with the consensus sequence YSPTSPS. Both the core motif and tandem ... -
Role Conception in New Graduate Nurses: A Secondary Analysis
(East Carolina University, 2017-05-03)Background: The new graduate transition to practice process affects retention, competency development, healthcare costs, quality, and assimilation into the profession. During the transition, new graduate nurses compare the ... -
Role of antidepressants in fetal synapse formation in Autism Spectrum Disorders
(East Carolina University, 2018-07-23)Autism is a genetically complex neurodevelopmental disorder in which patients exhibit social deficits in both verbal and non-verbal forms of communication and display restricted and repetitive behaviors. Approximately 1 ... -
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ... -
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
Role of Cold Fronts in South American Monsoon Onset
(East Carolina University, 2010)During the austral spring, the interactions between the southward-moving intertropical convergence zone with cold fronts that progress equatorward contribute to the complexity of the timing and regional differences in South ... -
The Role of Cultural Capital and Parental Involvement in Educational Achievement and Implications for Public Policy
(East Carolina University, 2011)Using the theory of social and cultural reproduction originally posited by Pierre Bourdieu, I test the idea that social status and individual culture affect academic achievement. The data used for this analysis was from ... -
Role of Dopamine Receptor 3 in Cardiac Fibrosis
(East Carolina University, 2021-12-20)Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these ... -
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
(East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ... -
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ... -
The Role of GSK-3[beta] in MCF-7 Breast Cancer Cell Signaling and Drug Resistance
(East Carolina University, 2011)Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of critical cellular processes. This versatile protein is involved in numerous signaling pathways that influence metabolism, ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ... -
Role of Macrophage Polarization and Apolipoprotein E in Granuloma Resolution
(East Carolina University, 2021-07-06)Sarcoidosis is a chronic disease characterized by the development and accumulation of granulomas. Through multiwall carbon nanotube (MWCNT) instillation of C57 Bl/6 (wild-type) mice, we have established a murine model that ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ...