Browsing Dissertations and Theses by Author "Chen, Yan-Hua"
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Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
Hoggard, John Elliott (East Carolina University, 2010)Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ... -
[Delta]-catenin: implications in prostate cancer progression
Nopparat, Jongdee (East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Functions of claudin-7 in human lung cancer
Lu, Zhe (East Carolina University, 2012)Lung cancer is the second most common cancer and the most common cause of cancer-related death in both men and women in the United States with a very poor overall 5-year survival rate. Nearly 95% of the lung cancer originates ... -
FUNCTIONS OF CLAUDIN-7 IN THE SELF-RENEWAL OF INTESTINAL EPITHELIUM
Xing, Tiaosi (East Carolina University, 8/5/2020)Tight junctions (TJ) are located at the most apical region of the junctional complex and contain many integral membrane proteins. Claudin 7 (Cldn7) is a TJ membrane protein located at the apical TJ and basolateral side of ... -
Investigating Non-Tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein Nanoarchitecture
Naser, Amna (East Carolina University, 2022-12-12)Edit this abstract. -
The Differential Roles of pH sensing G-Protein Coupled Receptors in Inflammation and Cancer
Marie, Mona Abdou Ahmed (East Carolina University, 2022-12-13)Intestinal inflammation is a burdening disease that may occur due to an aberrative immune response to certain drugs, infections, genetics, or unknown environmental factors. Inflammatory bowel disease (IBD) is of special ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
Kim, Do Hyung (East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...