Browsing Dissertations and Theses by Author "Engineering"
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A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY
Yaeger, Michael (East Carolina University, 2018-07-17)Cardiovascular and pulmonary diseases are leading causes of morbidity and mortality worldwide. Studies report an inverse correlation between levels of serum high-density lipoprotein (HDL) and the severity of cardiovascular ... -
A Patient-Specific Multiscale Model of Mechanical Ventilation of COVID-19-afflicted Lungs
Middleton, Shea Taran (East Carolina University, 2022-07-24)Coronavirus disease-2019 (COVID-19) is a respiratory disease that caused a worldwide pandemic and, in some cases, manifests as an acute respiratory distress syndrome. Severe cases of COVID-19 are often treated with mechanical ... -
A Patient-Specific Multiscale Model of Mechanical Ventilation of COVID-19-afflicted Lungs
Middleton, Shea Taran (East Carolina University, 2022-07-24)Coronavirus disease-2019 (COVID-19) is a respiratory disease that caused a worldwide pandemic and, in some cases, manifests as an acute respiratory distress syndrome. Severe cases of COVID-19 are often treated with mechanical ... -
Analysis of Electrospun Tβ4 Coated Scaffolds: A Tissue Engineering Study
Myers, Victoria (East Carolina University, 2019-07-18)Tissue engineering is a field within regenerative medicine that promotes the regeneration/repair of damaged or diseased tissue and organs. This field focuses on three aspects: cells, growth factors, and scaffolds to achieve ... -
Characterization and Biomimetic Fabrication Study of Fetal Membranes for Understanding and Prevention of Preterm Birth
Wheeler, Mackenzie L (East Carolina University, 2022-04-25)Preterm birth is defined as a baby being born before 37 weeks gestation and is a large problem, affecting 10% of all pregnancies in the United States and world annually. Preterm birth can result in lifelong complications ... -
CHARACTERIZATION OF PHOTORECEPTOR-CONTROLLED AGGREGATION AND DISAGGREGATION OF MICROPARTICLE SUSPENSIONS
Cone, Christopher B (East Carolina University, 2021-06-23)Phytochromes are a unique classification of photoreceptors used by plants to perceive light for many physiological processes. Phytochrome B (PhyB) possesses two interconvertible forms which can be activated under specific ... -
Chemical and Physical Correlates to Pain
Potts, John L (East Carolina University, 2018-12-12)The accurate measurement of pain is important to physicians for medical decision making. Pain is considered to be the largest health-related burden to society as well as the leading cause of long-term disability worldwide. ... -
Computational Modeling of Arteriovenous Fistula Hemodynamics in Pulmonary Hypertension Patients
Southern, Kaitlin M (East Carolina University, 2023-07-21)In the United States, approximately 50 million people suffer from chronic kidney disease, which over time progresses to end-stage renal disease (ESRD). Care for these patients is typically managed by dialysis with the ... -
COST-BENEFIT ANALYSIS OF 3D FINITE ELEMENT MODELING OF THE TIBIA USING A HEALTHY RUNNING POPULATION
Butler, Patricia (East Carolina University, 2021-07-29)Bone stress injuries (BSIs) are a common, painful injury in runners. Computational methods, like finite element analysis (FEA), are used to further understand BSI mechanisms. FEA can be performed on three-dimensional (3D) ... -
Creation of an Effective Manufacturing Supply Chain Utilizing Lean Best Practices
Lahiji, Narges (East Carolina University, 2021-12-03)The purpose of this experimental case study is to define best practices in supply chain and describe the effect of improvements in manufacturing efficiencies. It is essential to embed "Lean," "Agile" and "Intelligent" ... -
Development of a Heart Motion Tracking System using Non-invasive Imaging Data
Tucker, Bryent (East Carolina University, 2017-07-18)Cardiac motion can be monitored non-invasively for the assessment of cardiovascular function by using medical imaging systems and motion tracking algorithms. Existing tracking approaches require a priori understanding of ... -
Enhancing GNSS RTK Solutions with Random Sample Consensus
Krebs, Angela (East Carolina University, 2022-07-12)Precise positioning with Global Navigation Satellite Systems (GNSS) can be achieved by using the real-time kinematic (RTK) solution. A GNSS RTK solution was improved using an innovative approach based on Random Sample ... -
Enhancing GNSS RTK Solutions with Random Sample Consensus
Krebs, Angela (East Carolina University, 2022-07-12)Precise positioning with Global Navigation Satellite Systems (GNSS) can be achieved by using the real-time kinematic (RTK) solution. A GNSS RTK solution was improved using an innovative approach based on Random Sample ... -
EXPERIMENTAL DETERMINATION OF THERMOPHYSICAL PROPERTIES IN SUPERCRITICAL HEAT EXCHANGERS
Trapani, Michael J (East Carolina University, 2023-12-07)An ECU team designed, built, and is testing a pilot-scale supercritical water desalination (SWD) system that processed brine discharge from conventional desalination systems. The system completely separates the solid salts ... -
Experimental Studies of Flow-Structure Interactions in Blast/Shock-Driven Complex Flows
Zieg, Parker (East Carolina University, 2022-04-29)Blast waves, which are generated by the sudden energy release in a finite space, are encountered in various situations. As the blast/shock waves propagate, any object in its path can be damaged by the combination of ... -
EXPIDITING THE PROCESS: METHODOLOGY DEVELOPMENT FOR ONSITE SPORICIDAL AGENT EFFICACY TESTING AND SCREENING IN COMMERCIAL PHARMACEUTICAL SETTINGS
Axtman, Melinda Victoria Plyler (East Carolina University, 2021-11-29)Effective facility cleaning and disinfectant practices are crucial to the safe manufacturing of pharmaceutical products. Without an effective plant wide cleaning strategy, risk of site contamination, product adulteration ... -
EXPLORING THE EFFECTS OF OFFLINE PARADIGMS AND FEATURE EXTRACTION TECHNIQUES ON PERFORMANCE OF MOTOR IMAGERY BASED BRAIN-COMPUTER INTERFACE
Dick, Joelle F (East Carolina University, 2021-07-15)Motor Imagery (MI) Brain-Computer Interface (BCI) has become a popular way of allowing disabled and healthy individuals to use brain signals to communicate with their environment. However, despite its potential, MI-based ... -
Fluid Contact Angle Assessment to Evaluate Wetting of Dental Materials
Abdelsalam, Rana (East Carolina University, 2017-04-27)Dental crowns account for a large percentage of restorative dental procedures, but the crown materials have been shown to cause wear on the natural opposing tooth. There is uncertainty regarding which mechanical or chemical ... -
Functional Connectivity Analysis of Visually Evoked ERPs for Mild Cognitive Impairment
Wang, Lana (East Carolina University, 2022-04-28)Mild cognitive impairment (MCI) is considered as the early stage of Alzheimer's disease, characterized as mild memory loss. Using electroencephalogram (EEG) data, a novel method of functional connectivity (FC) analysis can ... -
Graph Theoretic analysis of the Human Brain Functional Connectivity Alteration Due to Sleep Restriction
Antar, Marwa (East Carolina University, 2023-05-03)Sleep plays a vital role in learning and memory consolidation. Several studies used brain models of sleep deprivation (SD) and insomnia to study the association between sleep deficiency and cognitive decline conditions. ...