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Developing Novel Chemotherapeutics: A Structure-Activity Study of Anandamide Analogs and their Cytotoxic Profiles
(East Carolina University, 2020-01-06)
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzyme responsible for both the metabolism of arachidonic acid (AA) to prostaglandins and arachidonoyl ethanolamine (AEA) to ...
INNOVATIONS IN HIGHER EDUCATION CLINICAL INSTRUCTOR TRAINING FOR OCCUPATIONAL THERAPY: A Program Evaluation
(East Carolina University, 2020-01-07)
The purpose of this study is to evaluate a clinical instructor program model by using a program evaluation research design to determine best practices for an open access clinical instructor training program. Evaluating the ...
Harriet Beecher Stowe and the Debate Between Frederick Douglass and Martin Delany
(East Carolina University, 2020-01-06)
Martin Delany had different ideas about Uncle Tom's Cabin than did Frederick Douglass. Delany wrote his concerns in a series of letters that were published in Douglass' newspaper. Delany stated that Harriet Beecher Stowe ...
CHARACTERIZATION AND DEVELOPMENT OF FRACTURE PATTERNS IN DOMED SEDIMENTARY STRATA, PULPIT ARCH, HENRY MOUNTAINS, UTAH
(East Carolina University, 2020-01-10)
Fractures in sedimentary rock can be an important factor in influencing fluid migration in the subsurface. In high-porosity sandstones in the upper crust, deformation such as folding typically results in the production of ...
FITNESS NON-RESPONSE FOLLOWING AEROBIC EXERCISE TRAINING IN OBESE AFRICAN AMERICANS
(East Carolina University, 2020-01-07)
Cardiorespiratory fitness (CRF) has been closely associated with cardiovascular disease (CVD) and all-cause mortality. An inverse relationship between CRF, and CVD and all-cause mortality has been well-established. To ...
Using Eye Tracking Technology To Compare Hazard Detection On Road Versus Driving Simulator At Night Across Two Age Groups
(2021-05-01)
Rationale: Though previous literature exists that demonstrates the validity of using driving
simulation compared to on-road driving, few studies have examined hazard detection between
two driving conditions. Even fewer ...
DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)
Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ...
A MIXED METHODS STUDY ON NURSING STUDENT STRESS, ANXIETY AND RESILIENCE DURING AN UNEXPECTED DEATH SIMULATION
(East Carolina University, 2021-07-15)
About one third of the more than 700,000 deaths that occur in hospitals each year are unanticipated. Without appropriate training and experience, a patient's impending death can be overwhelming, and an unexpected death can ...
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)
The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ...
Perceived Gender Roles and ADHD: An Explanation for the Diagnosis Gap
(East Carolina University, 2021-07-15)
In pursuit of explaining the diagnosis gap, in which more boys are diagnosed with ADHD than girls, two broad schools of thought emerge throughout the literature-one suggests the gap is due to inherent sex differences, and ...