Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ...

Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...

A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ...

The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ...

Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ...

Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...

It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ...

Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...

Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...