Browsing Dissertations by Title
Now showing items 971-990 of 1044
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THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
(East Carolina University, 2019-05-07)Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ... -
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
THERE’S TWO SIDES TO EVERY STORY: EXPANDING THE NOMOLOGICAL NETWORK OF BURNOUT THROUGH THE PERSON-ENVIRONMENT INTERACTION
(East Carolina University, 8/5/2020)Burnout is a psychological syndrome consisting of emotional exhaustion, cynicism, and reduced personal accomplishment. It is associated with a depletion of intrinsic resources that results from prolonged exposure to ... -
Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
(East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ... -
They're Speaking Gender Identity, Agency, and Belonging in an International Middle School
(East Carolina University, 2023-04-17)The purpose of the study was to better understand how international school middle school teachers can help cultivate a student’s sense of belonging by creating a space for students to explore factors shaping their gender ... -
THREAT ASSESSMENT AND MANAGEMENT: PROTOCOL AND BUDGETARY NEEDS FOR TOOLS AND MEMBER TRAINING IN HIGHER EDUCATION
(East Carolina University, 2021-04-20)The primary goal of threat assessment is to prevent individuals who are on a pathway to violence. Threat assessment entails a three-step process beginning with identifying a concern, assessing the risk and managing the ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ... -
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ... -
TLR-4 agonism induces CD25+ MHCIIhigh dendritic cells in association with tolerogenic antigen recognition
(East Carolina University, 2022-12-06)Autoimmune disease is a result of the breakdown in immunological self-tolerance leading to destruction of self-tissues mediated by the aberrant immune attack. In Multiple Sclerosis (MS), CD4+ T cells mediate destruction ... -
Toward a balanced demographic: A case study of parents's preference for rural charter schools
(East Carolina University, 2018-04-09)Against a background of failure on the part of the focus of this case study to adhere to its founding charter in terms of enrollment, the purpose of this study was to explore how and why rural parents choose charter schools ... -
Toward increasing leadership capacity in nurses: an exploration of the state and future perspectives of leadership education in pre-licensure baccalaureate nursing programs.
(East Carolina University, 2015)The purpose of this study was to explore and describe the state and future perspectives of leadership education in pre-licensure baccalaureate nursing programs. Study objectives were to describe nurse educator and practice ... -
Training Effects on Recovering Parents' Self-Efficacy to Identify Problems, Solutions and Resources to Prevent Internet Addiction in Youth
(East Carolina University, 2017-12-06)This study examined the effects of a 2-hour training on the self-efficacy of parents in recovery from substance use disorder to intercede in their children's Internet technology use in order to prevent future problems with ... -
Transcriptional regulation of 'pqsR', a gene that encodes a regulator of quinolone signal synthesis and virulence in 'Pseudomonas aeruginosa'
(East Carolina University, 2015)The gram-negative bacterium 'Pseudomonas aeruginosa' is an opportunistic pathogen that frequently causes nosocomial infections and serious chronic lung infections in cystic fibrosis patients. During infection 'P. aeruginosa' ... -
TRANSFORMING FAMILY ENGAGEMENT BY DEVELOPING THE CAPACITY OF SCHOOL LEADERS
(East Carolina University, 2021-04-27)This qualitative study was guided by the Dual-Capacity Building Framework for Family-School Partnerships (Mapp & Kuttner, 2013) to explore how elementary principals led family engagement; provided insights into what ... -
TRANSGENDER/GENDER NONBINARY STUDENTS WITH DISABILITIES: BEST PRACTICES FOR DISABILITY SUPPORT SERVICES PROVIDERS IN POSTSECONDARY EDUCATION
(East Carolina University, 2021-05-03)There are approximately 26,600 students of public higher education in the United States of America who identify as transgender/gender nonbinary and have at least one disability. Research has focused on these two marginalized ... -
Transition from Adult Education to Postsecondary Education
(East Carolina University, 2019-04-26)The Workforce Innovation and Opportunity Act (WIOA) that was signed into law in July 2014 by President Barack Obama gave a new identity to adult education programs across the United States. The legislation propelled adult ... -
Trauma, Coping, & the Couple Relationship : An Investigation of Pregnant Couples' Biopsychosocial-Spiritual Health
(East Carolina University, 2014)Pregnancy and trauma are each complex biopsychosocial-spiritual processes with implications for the couple relationship, but there is not enough research on the ways that the two constructs are connected. Two articles were ... -
Treating problem solving deficits in traumatic brain injury
(East Carolina University, 2014)Cognitive deficits following TBI are multidimensional. Current treatment programs approach problem solving training in a top-down approach with problem solving skill perceived independent of attentional control and working ... -
Treatment Adherence In Pediatric Sickle Cell Disease : Examining Medication Adherence, Appointment Keeping, And Self-Care Behaviors
(East Carolina University, 2015)The present study sought to ascertain whether treatment adherence in a pediatric SCD population is best described as a multidimensional or global construct by 1) examining the relationship between medication adherence, ... -
Trophically transmitted parasites as “cross-taxon surrogates” of biodiversity in coastal environments
(East Carolina University, 2022-06-01)Parasitism is a highly successful life history strategy, and estimates suggest that as much as 40% of life on earth is parasitic. Healthy ecosystems have high parasite diversity, which in turn reflects underlying patterns ...