The purpose of this study was to analyze the moral reasoning of university presidents and athletics directors in sport settings, an area into which few initiatives have been undertaken. Electronic surveys were used to ...

The purpose of this study was to examine the interpretive processes of administrators and staff at individual community colleges in the North Carolina system. The study examines how developmental education policy, established ...

The purpose of this study was to examine the relationship between how the freshman seminar course in extended orientation format is populated at a large research institution and its impact on student perception of content, ...

The leadership of the school principal has long been associated with teacher effectiveness and student achievement. Research on the topic of principal leadership supports this association (Hallinger, Bickman, & Davis, 1996; ...

The purpose of this research was to study the perspectives, characteristics, and experiences of ten distance education leaders at four-year, not-for-profit, degree-granting higher education institutions implementing online ...

This study analyzed the impact of school poverty levels on variances in elementary math achievement and preparation-based teacher effects. The research was conducted using data from the Gaston County School District, the ...

Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...

The University of North Carolina General Administration has required all constituent institutions with teacher education programs to expand their productivity goals to meet the state's teacher workforce needs. This study ...

Higher education administrators are continually trying to control the costs of Information Technology (IT) investments and demonstrate the value of IT to the organization. As many administrators implement structures and ...

Fertility and embryonic viability are measures of efficient germ cell growth and differentiation. During oogenesis, spermatogenesis and embryogenesis cells initially proliferate then differentiate into specific tissues. New proteins are required for both cell growth and differentiation, requiring qualitative and quantitative changes in protein synthesis. During late gametogenesis and early embryogenesis the expression of the appropriate proteins is a primarily due to translational control. Translational control of mRNAs is mediated in part by eukaryotic initiation factor 4E (eIF4E). eIF4E binds the methylated 5' cap of mRNA and recruits it to the ribosome. The nematode worm C.elegans expresses five isoforms of eIF4E (termed IFE-1 through 5). IFE-1 is expressed primarily in the germline and is the only isoform that associates with P granules by binding directly to PGL-1. P granules are ribonucleoprotein particles (RNPs) that contain stored mRNAs and proteins needed for oogenesis and early embryogenesis. Using a strain that lacks IFE-1, I assessed the translational efficiency of maternal mRNAs bound and not bound to P granules by polysome fractionation. Translation of pos-1, pal-1, mex-1, oma-1, ced-4 and glp-1 mRNAs was inefficient in the ife-1 strain relative to wild type worms. GAPDH (gpd-3) mRNA translation was not affected. We also observed differences in the pattern of expression of the MEX-1 protein during oogenesis. In males, secondary spermatocytes failed to complete cytokinesis at 25°C in absence of IFE-1. Males deficient of IFE-1 therefore lacked mature sperm. In addition, ife-1 spermatocytes prematurely accumulated pro-apoptotic CED-4, homolog to mammalian Apaf-1, during spermatogenesis. In ife-1 worms fertility was decreased by 80% due to decreased viability of both oocytes and spermatocytes. Our data indicate two unique roles for eIF4E (IFE-1 isoform) in late oogenesis and spermatogenesis. We suggest that IFE-1 preferentially recruits regulated mRNAs at critical times during germ cell development.  ...