Dissertations: Recent submissions
Now showing items 361-380 of 1044
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Inquiry: A Pedagogy for Personal Empowerment, Collaboration, and Democracy
(East Carolina University, 2019-11-27)Purpose: Inquiry-based pedagogy is rare within the educational landscape. It is even more rare for students who face multiple challenges to success, including racism and poverty. Inquiry- based pedagogy substantially ... -
Determining the role of the steroid hormone ecdysone in critical stages of Drosophila melanogaster early oogenesis
(East Carolina University, 2019-11-27)Reproductive function in many organisms, including Drosophila melanogaster, is controlled by steroid hormones. The main steroid hormone in Drosophila is ecdysone, which is structurally and functionally similar to estrogen. ... -
Implementing A Multi-Tiered System of Support to Increase Student Success
(East Carolina University, 2019-11-27)West Bladen High School implemented a Multi-Tiered System of Support (MTSS) model to improve student achievement, attendance, and behavioral outcomes for students at-risk of dropping out of school. With little guidance and ... -
Where Science Meets Users Needs: Storm Surge in Eastern NC
(East Carolina University, 2019-11-26)The coast is well researched because of its intrinsic value to visitors, the lives and property of those who live at the coast, and the environmental services it provides through tourism, natural resources, and as a natural ... -
A Brief Intervention to Reduce Sugar Consumption on College Campuses
(East Carolina University, 2019-11-26)Background: Research suggests that high sugar consumption is linked to a variety of health complications, including cardiovascular disease and diabetes. Previous research also suggests that adolescents and young adults ... -
Development of Green Subcritical Water Separation Technology
(East Carolina University, 2019-08-19)Theoretically speaking, water under temperature and pressure conditions below its critical point is called subcritical water. However, the term “subcritical water” normally refers to hot water up to 374 C and pressure up ... -
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ... -
RE-IMAGINING PRINCIPAL SUPPORT: A PARTICIPATORY ACTION RESEARCH PROJECT TO ENGAGE PRINCIPALS IN AN EQUITY-CENTERED PROFESSIONAL LEARNING COMMUNITY
(East Carolina University, 2019-12-12)The aim of the PAR project was to engage principals in meaningful professional learning opportunities that supported their growth and development as school and community leaders by participating in an Equity Centered ... -
WOMEN’S OBESITY AND SEXUAL QUALITY: A DYADIC STUDY ON WOMEN AND THEIR MALE PARTNERS
(East Carolina University, 2019-12-04)Research supports a relationship between people with obesity and decreases in psychosocial functioning as it relates to their sexual health. While sexual health problems are more commonly found in women with obesity than ... -
Stiffness of Intrinsic Foot Structures in Diabetic Individuals and the Effect of Stiffness on Plantar Pressures During Gait
(East Carolina University, 2020-01-06)Plantar foot ulcers are a severe and common complication associated with diabetes that overwhelmingly lead to non-traumatic major amputations among diabetic individuals. There are several known factors that contribute to ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ... -
THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
(East Carolina University, 2019-07-26)Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
(East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ... -
Targeting Psychological Flexibility in Youth to Enhance Health-Related Behaviors
(East Carolina University, 2019-07-22)Background: Adolescents are uniquely vulnerable to a wide range of psychological issues and often, concerns inadequately addressed. When addressed, mental health concerns are commonly handled in schools, which are uniquely ... -
Examination of Nutrition Monitoring through Ecological Momentary Assessment during an Internet-based, Self-directed Weight Loss Intervention
(East Carolina University, 2019-07-09)Internet and mobile health (mHealth) based interventions are promising potential options for increasing access to weight loss treatment for the general public (Payne et al., 2015). Many health-related internet and mobile ... -
Interim Assessments as a Predictive Tool and Driver of Formative Assessment Practices to Improve Student Performance on State Assessments
(East Carolina University, 2019-07-08)The problem of practice on which this study focused was the establishment of interim assessments as a predictive tool and driver of formative assessment practices to improve student performance. The initial phase of ... -
On Edge: A Techné of Marginality
(East Carolina University, 2019-07-24)Technical and professional communication has traditionally been rooted in the white, Western, hetero-patriarchal rhetorical tradition and bound by rigid notions of objectivity and neutrality that exclude historically ... -
THE EFFECTIVENESS OF JOB CARD GROUNDING IN AN INTERMEDIATE CARE FACILITY FOR INDIVIDUALS WITH INTELLECTUAL DISABILITY
(East Carolina University, 2019-08-05)Despite limited research, Job Card Grounding (JCG) remains a highly recommended clinical intervention for defiant adolescents, with many medical and parenting websites advocating for its use. The purpose of the current ...