Dissertations: Recent submissions
Now showing items 601-620 of 1044
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Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
(2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
Alterations in insulin action and contraction-mediated metabolism in myotubes derived from Roux-en-Y gastric bypass patients
(5/16/2016)Roux-en-Y gastric bypass (RYGB) surgery induces various metabolic benefits in severely obese (BMI> 40 kg/m2) individuals, including improved insulin action in peripheral tissues, most notably skeletal muscle, and remission ... -
Multilevel Discourse Processing Analyses in Adults with a Cognitive Impairment
(East Carolina University, 2016-12-13)Participants with a cognitive impairment associated with Alzheimer's disease (AD) present with discourse impairments early within the disorder. These discourse impairment are associated with declines in episodic, semantic, ... -
Predicting length of treatment involvement of substance using perinatal women in an integrated inpatient healthcare program
(East Carolina University, 2016-12-16)Services for perinatal (pregnant and one year postpartum) women are limited, and inpatient settings where women receive substance abuse services specific to the perinatal population, although ideal, are rare in eastern ... -
A STUDY OF THE PERCEPTIONS OF THE EFFECTIVENESS OF TRADE AND INDUSTRIAL EDUCATION IN THE PREPARATION OF GRADUATES FOR EMPLOYABILITY AND POST-SECONDARY EDUCATION
(East Carolina University, 2016-12-13)This dissertation was a mixed method study that examined the perceptions of the effectiveness of trade and industrial education of graduates' employability and post-secondary education. The purpose of this study was to ... -
Quality of life in school-age children with obesity, the experiences of school nurses, and moral distress associated with care delivery
(East Carolina University, 2016-11-16)Childhood obesity is a multifaceted, complex problem that is associated with many other chronic health conditions. School nurses are well positioned to assess, intervene, and evaluate efforts to positively impact this ... -
Re-evaluation of coastal cultural heritage resources : case study of North Carolina southeastern coastal region
(East Carolina University, 2016-12-15)Humans have had a long history of interconnectedness with the sea and ocean due to the use of natural resources available in the coastal areas. These interactions have influenced the natural landscape and played a crucial ... -
Massive open online courses and completion rates: does academic readiness and its factors influence completion rates in MOOCs?
(East Carolina University, 2016-12-06)With the increase in the cost of an education and the flat employment rate, many institutions and students are looking to online learning to solve this academic dilemma. Online education is thought to be a low-cost academic ... -
AN INVESTIGATIVE STUDY OF THE NEUROPSYCHOLOGICAL AND NEUROPHYSIOLOGICAL FEATURES OF SUBJECTIVE SLEEP QUALITY
(East Carolina University, 2016-12-06)Background: Disordered sleep is a national health issue affecting an estimated 50-70 million US adults. The documented consequences of disordered sleep include impaired daily function, increased risk for chronic health ... -
ADVANCING STUDENT SUCCESS AND COLLEGE COMPLETION FOR NONTRADITIONAL STUDENTS: AN EXAMINATION OF DISTANCE EDUCATION PARTICIPATION AND DEGREE ATTAINMENT
(East Carolina University, 2016-12-06)This quantitative ex post facto study examined the relationship between online programming and persistence for the nontraditional student population in higher education. Colleges and universities today are increasing their ... -
EXAMINATION OF TREADMILL STRESS TEST EXPOSURE THERAPY FOR PEDIATRIC CARDIAC DEVICE PATIENTS (TreadExpo)
(East Carolina University, 2016-09-16)Pediatric patients with cardiac devices report fear and anxiety associated with exertion and activity resulting in high avoidance of activities, things, or places post-device implant. Extant pediatric cardiac literature ... -
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ... -
ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
(East Carolina University, 2016-12-15)Type 2 diabetes affects ~25 million people in the U.S., and is the primary cause of non-traumatic lower limb amputation and the leading cause of blindness in adults. Major risk factors for the development of type 2 diabetes ... -
TEACHER FACTORS RELATED TO ACCEPTABILITY AND ADOPTION OF GROUP CONTINGENCY INTERVENTIONS FOR DISRUPTIVE BEHAVIOR
(East Carolina University, 2016-12-15)Disruptive behavior is a frequent problem in many American classrooms, especially in schools with large populations of low income students. Nevertheless, many teachers do not use evidence based behavior management strategies. ... -
Rules of (employee) engagement: A comprehensive model
(East Carolina University, 2016-12-15)The purpose of the study was to examine a comprehensive model of employee engagement that included a diverse set of (1) personal factors, (2) environmental factors, (3) job attitudes, (4) work outcomes and (5) health ... -
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ... -
Attachment-Based Treatment for Pediatric Obesity in Integrated Behavioral Health Care
(East Carolina University, 2016-12-16)Pediatric obesity is a growing health concern afflicting the United States. Pediatric obesity, as a health epidemic, not only costs billions of dollars to our nation, but also negatively impacts the biological, psychological, ... -
The Integrated 50-Minute Hour: Person-Centered Counseling and Heart Rate Variability Biofeedback Training
(East Carolina University, 2016-12-13)The field of mental health has moved toward new approaches for the improvement of treatment through the application of knowledge regarding human anatomy and mental health symptomology. Mental health research and education ... -
Peroxisomal-Mitochondrial Metabolic Interactions in Lipid Metabolism in Human Skeletal Muscle
(East Carolina University, 2016-11-16)Peroxisomal activity and associated functions, including [beta]-oxidation contributions toward maintaining cellular lipid homeostasis, is poorly defined in extra hepatic tissues, most especially in human skeletal muscle ...