Dissertations: Recent submissions
Now showing items 621-640 of 1044
-
Linking energy state to redox environment through mitochondrial redox circuits
(East Carolina University, 2016-11-16)Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ... -
Unravelling the mechanisms of menopause-induced insulin resistance: novel roles for estradiol in skeletal muscle mitochondrial function
(East Carolina University, 2016-11-16)Menopause results in a progressive decline in ovarian production of 17[beta]-estradiol (E2), increased adiposity and a higher risk for type-2 diabetes, but hormone replacement therapies containing E2 reverse most of these ... -
Velopharyngeal Muscle Morphology in Children with Congenital Palatal Microforms
(East Carolina University, 2016-12-15)Children born with palatal microforms are often clinically mismanaged due to difficulties in diagnosis and treatment. These difficulties are exacerbated by anatomical and physiological differences in clinical presentation. ... -
Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration
(East Carolina University, 2016-09-08)Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial ... -
Impact of Muscle Material Properties on the Hypertrophic Response of Aged Women to Resistance Exercise
(East Carolina University, 2016-07-21)All of the reports that comprise this dissertation center around the overarching hypothesis that the attenuated response to resistance exercise observed in older adults is caused by an impaired ability of the muscle to ... -
Delination of Coastal Shark Habitat within North Carolina Waters Using Acoustic Telemetry, Fisher-Independent Surveys, and Local Ecological Knowledge
(East Carolina University, 2016-07-20)Knowledge of shark habitat preferences and use patterns is important to effectively manage shark fisheries and account for interactions between sharks and species targeted by other fishery management or conservation efforts. ... -
VICTIM ADVOCACY IN HIGHER EDUCATION
(East Carolina University, 2016-07-08)Public institutions of higher learning are required by The Jeanne Clery Disclosure of Campus Security Policy and Campus Statistics Act 1990 (20 USC [section] 1092(f)) to provide education on crime prevention to constituents ... -
The Effect of Noise Exposure on Auditory Threshold, Otoacoustic Emissions, and Electrocochleography
(East Carolina University, 2016-07-25)Noise exposure is the second leading cause of acquired sensorineural hearing loss and is one of the most common occupational and environmental hazards. Examining changes in behavioral thresholds has long been the standard ... -
Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
(East Carolina University, 2016-07-25)The prevalence of obesity is exponentially increasing worldwide. Although strategies such as exercise, nutritional intervention, and pharmaceutical therapies including resveratrol have been extensively studied in lean or ... -
Exploring the roles of horizotnal gene transfer in metazoans
(East Carolina University, 2016-07-20)Horizontal gene transfer (HGT; also known as lateral gene transfer, LGT) refers to the movement of genetic information between distinct species by overcoming normal mating barriers. Historically HGT is only considered to ... -
Characterization of FtrABCD: a ferrous iron-specific transporter that is required for the virulence of Brucella abortus 2308 in mice
(East Carolina University, 2016-07-21)Brucella strains are Gram-negative bacteria that cause abortion and infertility in their natural animal hosts resulting in extensive economic losses. Humans can acquire a chronic, debilitating febrile illness known as ... -
Procedural Pain in Pediatric Sickle Cell Disease: The Effect of Parental Behaviors and Anxiety
(East Carolina University, 2016-07-28)This study examined the impact of parental behaviors and anxiety on children's procedural coping behaviors, pain, and distress during venipuncture in a pediatric sickle cell disease (SCD) population. The first specific aim ... -
A phenomenological investigation of Spanish-English bilingual supervisees’ experience in clinical supervision
(East Carolina University, 2016-07-20)With a growing number of American households speaking languages other than English, the counseling profession must meet the counseling needs of non-English speaking clients. In turn, clinical supervisors and counselor ... -
Fear of Aquatic Predators Cause Prey to Alter Their Phenotype at Multiple Life Stages
(East Carolina University, 2016-07-27)Many organisms can alter their behavior, life history, and morphology in response to their environment. This ability is known as phenotypic plasticity. One of the major environmental cues that triggers a phenotypic plastic ... -
WORLDVIEW AS A PREDICTOR OF HEALTH RISK BEHAVIOR FOLLOWING SEXUAL VICTIMIZATION: MODERATED MEDIATION IN AN ETHNICALLY DIVERSE COMMUNITY SAMPLE
(East Carolina University, 2016-07-20)Sexual victimization has been associated with many adverse health outcomes including substance dependence, reproductive health issues, and increased somatic complaints, as well as risk for re-victimization. Engagement in ... -
Vectors of transmission: An early nicotine puff triggers a long-lasting microRNA molecular “memory” in C. elegans.
(East Carolina University, 2016-06-16)The prevalence of passive and active nicotine exposure among neonates, children and adolescents remains relatively high and varies among cultures and countries. Currently, there is ample evidence that a safe nicotine dose ... -
Development of the Peripartum Cardiomyopathy Quality Of Life Registry
(East Carolina University, 2016-07-08)Peripartum cardiomyopathy (PPCM) is a relatively rare form of heart failure that develops in young women in the third trimester of pregnancy or during the postpartum period. Despite its potentially devastating impact on ... -
Variations in Craniofacial and Velopharyngeal Structures Among Individuals with 22q11.2 Deletion Syndrome
(East Carolina University, 2016-07-25)22q11.2 deletion syndrome is the most common genetic cause of velopharyngeal dysfunction. Studies examining 22q11.2 deletion syndrome have thus far primarily focused on variations in the bony framework. Limited information ... -
An Exploration of Heart Failure Readmission in Eastern North Carolina
(East Carolina University, 2016-07-27)The purpose of this study is to identify and associate the level of patient activation and presence of comorbidities with early readmission, hospital discharge disposition, length of stay, number of admissions and all-cause ... -
COLLABORATION IN THE LOOSELY COUPLED ACADEMY
(East Carolina University, 2016-04-26)This dissertation examines how loosely coupled university units collaborate in the achievement of institutional wide goals. Today's higher education institutions are being asked to do more with less as resources have ...