Browsing Master's Theses by Subject "Microbiology"
Now showing items 1-14 of 14
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CRABS & ‘CROBES: THE TRIPARTITE RELATIONSHIP OF A HOST, PARASITE, AND THEIR RESPECTIVE MICROBIOMES
(East Carolina University, 8/5/2020)Growing evidence suggests that the associated microbiome of organisms (the holobiont) has been shaping the evolutionary pathways of macroorganisms for thousands of years, and that these tiny symbionts can influence species ... -
Determining the Chemical Structure of Brucebactin: The Sole Complex Siderophore Utilized by the Pathogenic Bacterium Brucella Abortus
(East Carolina University, 1/13/16)Brucellosis is a zoonotic bacterial disease that affects many around the world. There are over half a million new cases each year and prevalence rates in some areas of the world exceed 10 new cases per 100,000 in the ... -
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
(East Carolina University, 2012)Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ... -
Effects Of Nutrient Availability And Disturbance On The Composition And Diversity Of Soil Microorganisms
(East Carolina University, 2015)Determining how factors such as disturbance and nutrient availability affect species diversity in a community has been a major goal of community ecology. The purpose of this study was to look at how species diversity and ... -
Elucidating "Consumption" : Using Fluorescent Steroid Probes to Understand Host Cholesterol Utilization by Mycobacterium spp.
(East Carolina University, 2014)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, is the leading cause of death due to bacterial infection worldwide, claiming nearly two million lives each year. Often, the immune system ... -
The Fur-like regulator Mur controls the expression of the gene encoding the manganese transporter MntH in Brucella abortus 2308 in response to manganese availability
(East Carolina University, 2011)Brucella abortus is a Gram-negative, [alpha]-proteobacterium that causes bovine brucellosis, a prevalent zoonotic disease in many areas of the world. Brucella abortus is an intracellular pathogen that survives and ... -
Investigating the Microbial Communities Associated with Aluminum Alloys 2024 and 7075
(East Carolina University, 2020-11-17)Aluminum (Al), one of the most versatile, cost-effective, and appealing metals for use in construction, has no known biological function. Al alloys in aquatic environments provide a surface for attachment and can be ... -
Investigating the Relationship Between Zetaproteobacteria and Cyanobacteria and its Implications for the Geological Record
(East Carolina University, 2022-07-14)Banded Iron Formations (BIFs) are geological relics of the ancient oceans that were partially formed by microorganisms. This includes oxygenic phototrophs and iron-oxidizing bacteria (FeOB) whose relative contributions are ... -
Microbial Carbon Assimilation within the Walls of Deep-sea Hydrothermal Vent Chimneys
(East Carolina University, 2011)Carbon is one of the most abundant elements on Earth stored in a multitude of reservoirs and constantly cycled through various processes occurring on our planet. Although it represents only a small percentage of the total ... -
MICROBIAL DIVERSITY AND BIOGEOGRAPHY IN A SERPENTINITE-HOSTED ECOSYSTEM
(East Carolina University, 2010)The goal of this project was to characterize the taxonomic and functional diversity and document biogeographic patterns of microbial communities in an ecosystem influenced by active serpentinization. Serpentinization is a ... -
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
(East Carolina University, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ... -
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ... -
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ... -
Transcriptional Analysis of the Bacteroides fragilis Starch Utilization Operon, osuA
(East Carolina University, 2011)The opportunistic pathogen Bacteroides fragilis is a symbiotic organism that inhabits the human gastrointestinal tract where it utilizes dietary and host-derived polysaccharides as carbon and energy sources. If abdominal ...