Browsing Master's Theses by Subject "Musculoskeletal system"
Now showing items 1-9 of 9
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Comparison of Scaled vs. Ultrasound Based Musculoskeletal Models on Knee Muscle Moments During Single-Leg Squatting
(East Carolina University, 2012)Muscles produce force, resulting in moments about a joint, causing movement of the body. Muscle forces are estimated with a Hill-type model incorporating four parameters; optimal fiber length (OFL), tendon slack length, ... -
ENHANCED INSULIN SIGNALING FOLLOWING CONTRACTILE ACTIVITY IS BLUNTED IN MYOTUBES FROM SEVERELY OBESE INDIVIDUALS WITH OR WITHOUT TYPE 2 DIABETES
(East Carolina University, 2018-06-11)Introduction: Regular exercise has been known to improve insulin sensitivity in obese/ Type 2 Diabetic (T2D) individuals. However, some obese and T2D individuals do not respond well to regular exercise in their metabolic ... -
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ... -
Increased Degradation of Adenosine Monophosphate as a Regulator of Maximal Mitochondrial Respiration
(East Carolina University, 2019-07-02)Atrophied skeletal muscle have enhanced fatigability due at least in part to a reduction of mitochondria content. Mitochondrial biogenesis is regulated by the transcriptional coactivator PGC-1 alpha, which in turn is ... -
Metabolic Flexibility in Non-Obese Individuals
(East Carolina University, 2020-06-22)Human skeletal muscle cells have been used as a tool to study and understand skeletal muscle metabolism due to their retention in characteristics from their donor. Metabolic flexibility is the ability to respond or adapt ... -
Mitochondrial Oxidative Capacity In Human Skeletal Muscle: Association with Plasma Lactate Concentration
(East Carolina University, 2018-07-11)ABSTRACT Background: Metabolic disease is a growing concern for public health. Obesity and Type II Diabetes are an epidemic and a phenotype for insulin resistance in human skeletal muscle. A reduced mitochondrial function ... -
Muscle Work Discrepancy during Incline and Decline Running at Three Speeds
(East Carolina University, 2009)Introduction: Previous research has explored muscle function during gait and this work has shown that more positive mechanical muscle work is produced in gait tasks that primarily raise the center of mass (incline gait ... -
Relationships Among Measures of Strength and Power and Health Outcomes in Youth
(East Carolina University, 2014)The interest in musculoskeletal fitness and its overall impact on health has been increasing in the last decade. The Institute of Medicine (2012) report called for the addition of several muscular fitness tests to national ... -
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
(East Carolina University, 2012)Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ...