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The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)
CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ...
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)
Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ...
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)
Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ...
Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
(East Carolina University, 2015)
Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ...
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)
Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ...
Metabolic, Physiological, And Behavioral Responses Of Prey To Predation
(East Carolina University, 2015)
Predators are known to cause prey to alter their morphology, life history or behavior in ways that reduce the likelihood of the prey being consumed by the predator. Seldom considered, however, are the consequences of ...
Possible Effects Of Climate Change On Induced Defenses In Tadpoles
(East Carolina University, 2015)
Global climates are changing and the rate of change is expected to increase in the next century. Researchers predict that temporary ponds will be affected, resulting in shorter average hydroperiods (the amount of time a ...
Assessing The Monophyly Of Red Algae And Green Plants Via Core Conserved Informational Genes
(East Carolina University, 2015)
For well over a century the existence of a monophyletic relationship between red algae and green plants has been debated. Many scholars have sought to address this issue, however, a consistent solution to the problem has ...
The Effects Of Environmental Variation On Individual Variation
(East Carolina University, 2015)
Despite general consensus among ecologists that variation is ubiquitous and important in nature, ecological experiments have historically focused on changes in mean response assuming a constant environment and interchangeable ...
Reproductive Plasticity In Two Subspecies Of A Cleistogamous Plant, Triodanis Perfoliata
(East Carolina University, 2015)
Dimorphic cleistogamy is an intriguing reproductive strategy in which a plant produces both closed (cleistogamous), obligately selfing flowers and open (chasmogamous) flowers. Phenotypic plasticity in the production of ...