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Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium
(East Carolina University, 2004-01)
In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily ...
Assessing Children's Physical Activity in Their Homes: The Observational System for Recording Physical Activity in Children-Home
(East Carolina University, 2009)
The present study describes the development and pilot testing of the Observation System for Recording Physical Activity in Children-Home version. This system was developed to document physical activity and related physical ...
AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
(East Carolina University, 2009-05-01)
One characteristic of aging skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK)occurs in response to an increased AMP/ATP ratio,which is one potential result of ...
Exercise Training Amount and Intensity Effects on Metabolic Syndrome (From Studies of a Targeted Risk Reduction Intervention through Defined Exercise)
(East Carolina University, 2007-12-15)
Although exercise improves individual risk factors of the metabolic syndrome (MS), there is little research on the effect of exercise on MS as a whole. The objective of this study was to determine how much exercise is ...
Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle
(East Carolina University, 2006-07-01)
Impaired overload-induced protein synthesis and growth in aged fast-twitch skeletal muscle may result from diminished responsiveness of signalling intermediates controlling protein translation. Yet, potential age-related ...
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
(East Carolina University, 2009-07-28)
Background: Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently ...
Regulation of GLUT4 expression in denervated skeletal muscle
(East Carolina University, 2009-03)
Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known about the signaling events that cause this decrease. Experiments were designed to test the ...
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
(East Carolina University, 2009-01)
OBJECTIVE- Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, ...
Dietary carbohydrate intake and high sensitivity C reactive protein in at-risk women and men
(East Carolina University, 2007-11)
Background— The quality and quantity of dietary carbohydrate intake, measured as dietary glycemic load (GL), is associated with a number of cardiovascular disease (CVD) risk factors and, in healthy young women, is related ...
Muscle work is biased toward energy generation over dissipation in non-level running
(East Carolina University, 2008-12-05)
This study tested the hypothesis that skeletal muscles generate more mechanical energy in gait tasks that raise the center of mass compared to the mechanical energy they dissipate in gait tasks that lower the center of ...