Search
Now showing items 11-20 of 24
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ...
Intramuscular Lipid Metabolism, Insulin Action and Obesity
(East Carolina University, 2009-01)
With the increasing prevalence of obesity, research has focused on the molecular mechanism(s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations within muscle, such as changes in the cellular ...
Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
(East Carolina University, 2009)
The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ...
Relationships between Adipose Tissue and Cytokine Responses to a Randomized Controlled Exercise Training Intervention
(East Carolina University, 2008-04)
Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training ...
IL-15 : A NOVEL REGULATOR OF LIPOLYSIS IN HUMANS?
(East Carolina University, 2014)
Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ...
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)
Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...
The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
(East Carolina University, 2012)
Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...
EFFECT OF A TELEPHONE-BASED INTERVENTION ON PHYSICAL ACTIVITY AND COMPONENTS OF THE METABOLIC SYNDROME IN ADOLESCENTS
(East Carolina University, 2013)
The purpose of this study was to determine the effects of a two month telephone-based intervention in obese adolescents (BMI percentile [greater than or equal to] 95th percentile) on physical activity habits and motivation ...
THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ...
The Relationship between Gait Biomechanics and Body Mass Index
(East Carolina University, 2014)
Walking gait is one of the basic components of human movements. With the rising obesity epidemic and implied health complications, it is pertinent to examine the relationship between body mass index and the joint torques ...