Browsing Microbiology and Immunology by Title
Now showing items 75-94 of 268
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Effect of in vitro transcription on cruciform stability.
(East Carolina University, 1990-05-11)We have investigated the effect of in vitro transcription on cruciform stability. Replicative form DNA of 4X174 strain ins6240, containing a 48 bp synthetic palindrome in the J-F intercistronic region, was supercoiled in ... -
Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity
(2012-10)Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ... -
Effects of palindromes on in vivo DNA replication and mutagenesis in bacteriophage phi X174 RF DNA.
(East Carolina University, 1988-11-25)Bacteriophage IX174 mutants with insertions of palindromic DNA sequences are rapidly outgrown by competing wild-type phage (Muller & Turnage, J. Mol. Biol. 189: 285). The basis for this defect was investigated and found ... -
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology
(2010-08)The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation. The cancer stem ... -
Emerging targeted therapies for melanoma treatment (Review)
(2014-08)Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development ... -
Enforced expression of HoxA9 in b-lineage all promotes survival and proliferation of leukemic cells
(East Carolina University, 2009)HoxA9 is frequently overexpressed in acute myeloid leukemia, myelodysplastic syndrome and a subset of acute lymphoblastic leukemia. In mouse models, HoxA9 has been shown to promote leukemogenesis. In spite of a seemingly ... -
Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins
(East Carolina University, 2001-06-10)DNA vaccination can elicit both humoral and cellular immune responses and can confer protection against several pathogens. However, DNA vaccines expressing the envelope (Env) protein of human immunodeficiency virus (HIV) ... -
Enhancement of Antibodies to the Human Immunodeficiency Virus Type 1 Envelope by Using the Molecular Adjuvant C3d
(East Carolina University, 2003-02)DNA vaccines expressing the envelope (Env) protein of the human immunodeficiency virus have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies in a variety of animal models. In this ... -
Essential Role of the Iron-Regulated Outer Membrane Receptor FauA in Alcaligin Siderophore-Mediated Iron Uptake in Bordetella Species
(East Carolina University, 1999-10)Phenotypic analysis using heterologous host systems localized putative Bordetella pertussis ferric alcaligin transport genes and Fur-binding sequences to a 3.8-kb genetic region downstream from the alcR regulator gene. ... -
Experimental autoimmune encephalomyelitis as a model of Multiple Sclerosis : pathogenesis of atypical disease and tolerance induction in chronic progressive disease
(East Carolina University, 2015)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin characterized by focal inflammatory lesions together with demyelinating plaques in the ... -
Expression of hemolysins in vivo and role of HlyBA in an intra-abdominal infection model
(2013-04)Bacteroides fragilis is the most frequent opportunistic pathogen isolated from anaerobic infections. However, there is a paucity of information regarding the genetic and molecular aspects of gene expression of its virulence ... -
The Extracellular Domain of Myelin Oligodendrocyte Glycoprotein Elicits Atypical Experimental Autoimmune Encephalomyelitis in Rat and Species
(2014)Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical ... -
The Flat-Ribbon Configuration of the Periplasmic Flagella of Borrelia burgdorferi and Its Relationship to Motility and Morphology
(East Carolina University, 2009-01)Electron cryotomography was used to analyze the structure of the Lyme disease spirochete, Borrelia burgdorferi. This methodology offers a new means for studying the native architecture of bacteria by eliminating the chemical ... -
FliL Ring Enhances the Function of Periplasmic Flagella
(2022-03-07) -
Function and regulation of the polysaccharide utilization locus, don, in the gut symbiont bacteroides fragilis
(East Carolina University, 2014)Bacteroides fragilis is the most common anaerobe isolated from clinical infections and in this report we demonstrate a novel feature of the species that is critical to their success as an opportunistic pathogen. Among the ... -
FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION
(East Carolina University, 2015-12-10)KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma ... -
Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa
(East Carolina University, 2002-12)A set of 30 mutants exhibiting reduced production of the phenazine poison pyocyanin were isolated following transposon mutagenesis of Pseudomonas aeruginosa PAO1. The mutants could be subdivided into those with defects in ...