Browsing Microbiology and Immunology by Title

Now showing items 143-162 of 193

  • Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood 

    Piazzi, Manuela; Williamson, Andrew; Lee, Chia-Fang; Pearson, Stella; Lacaud, Georges; Kouskoff, Valerie; McCubrey, James A.; Cocco, Lucio; Whetton, Anthony D. (2015-05)
    Murine embryonic stem (ES) cells can differentiate in vitro into three germ layers (endodermic, mesodermic, ectodermic). Studies on the differentiation of these cells to specific early differentiation stages has been aided ...

  • Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa 

    Pesci, Everett C.; Milbank, Jared B. J.; Pearson, James P.; McKnight, Susan L.; Kende, Andrew S.; Greenberg, E. Peter; Iglewski, Barbara H. (East Carolina University, 1999-09-28)
    Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ...

  • Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection 

    Hamden, Khalief E.; Ford, Patrick W.; Whitman, Audy G.; Dyson, Ossie F.; Cheng, Shi-Yuan; McCubrey, James A.; Akula, Shaw M. (East Carolina University, 2004-12)
    Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ...

  • Raman spectroscopy: the gateway into tomorrow's virology 

    Lambert, Phelps J.; Whitman, Audy G.; Dyson, Ossie F.; Akula, Shaw M. (East Carolina University, 2006-06-28)
    In the molecular world, researchers act as detectives working hard to unravel the mysteries surrounding cells. One of the researchers' greatest tools in this endeavor has been Raman spectroscopy. Raman spectroscopy is a ...

  • Raman tweezers provide the fingerprint of cells supporting the late stages of KSHV reactivation 

    Dyson, Ossie F.; Ford, Patrick W.; Chen, De; Li, Yong-Qing; Akula, Shaw M. (East Carolina University, 2009-08)
    Kaposi's sarcoma-associated herpesvirus (KSHV) has both latent and lytic phases of replication. The molecular switch that triggers a reactivation is still unclear. Cells from S phase of cell cycle provide apt conditions ...

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance 

    McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Franklin, Richard A.; Montalto, Giuseppe; Cervello, Melchiorre; Libra, Massimo; Candido, Saverio; Malaponte, Graziella; Mazzarino, Maria C.; Fagone, Paolo; Nicoletti, Ferdinando; Bäsecke, Jörg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Milella, Michele; Tafuri, Agostino; Chiarini, Francesca; Evangelisti, Camilla; Cocco, Lucio; Martelli, Alberto M. (2012-10)
    The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health 

    Chappell, William H.; Steelman, Linda S.; Long, Jacquelyn M.; Kempf, C. Ruth; Abrams, Stephen L.; Franklin, Richard A.; Bäsecke, Jörg; Stivala, Franca; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Mazzarino, Maria C.; Nicoletti, Ferdinando; Libra, Massimo; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Montalto, Giuseppe; Cervello, Melchiorre; Laidler, Piotr; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Evangelisti, Camilla; Cocco, Lucio; Martelli, Alberto M.; McCubrey, James A. (2011-03)
    The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...

  • RecA and RadA Proteins of Brucella abortus Do Not Perform Overlapping Protective DNA Repair Functions following Oxidative Burst 

    Roux, Christelle M.; Booth, Natha J.; Bellaire, Bryan H.; Gee, Jason M.; Roop, R. Martin II; Kovach, Michael E.; Tsolis, Renee M.; Elzer, Philip H.; Ennis, Don G. (East Carolina University, 2006-07)
    Very little is known about the role of DNA repair networks in Brucella abortus and its role in pathogenesis. We investigated the roles of RecA protein, DNA repair, and SOS regulation in B. abortus. While recA mutants in ...

  • Recent discoveries in the cycling, growing and aging of the p53 field 

    McCubrey, James A.; Demidenko, Zoya N. (2012-12)
    The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. ...

  • Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes 

    Berman, Albert E.; Leontieva, Olga V.; Natarajan, Venkatesh; McCubrey, James A.; Demidenko, Zoya N.; Nikiforov, Mikhail A. (2012-12)
    It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm ...

  • Recent progress in targeting cancer 

    Demidenko, Zoya N.; McCubrey, James A. (2011-12)
    In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new ...

  • The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis 

    Rocha, Edson R.; Owens, Gary Jr; Smith, C. Jeffrey (East Carolina University, 2000-09)
    The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ...

  • Regulation of KSHV replication by glycoprotein B: chronicles of a virus and its host 

    Dyson, Ossie F. (East Carolina University, 2011)
    Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of three cancers: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic form of multicentric Castleman disease (MCD), shares many ...

  • The regulation of anthranilate synthesis for the production of pqs in pseudomonas aeruginosa 

    Knoten, Claire A. (East Carolina University, 2013)
    The ubiquitous bacterium P. aeruginosa is an important human pathogen that causes devastating infections in immunocompromised patients and chronic infections in cystic fibrosis patients. The ability of P. aeruginosa to ...

  • Regulation of Bacteriodes fragilis katB mRNA by oxidative stress and carbon limitation. 

    Rocha, Edson R.; Smith, C. Jeffrey (East Carolina University, 1997-11)
    Regulation of the katB catalase gene in the anaerobic bacterium Bacteroides fragilis was studied. Northern blot hybridization analyses revealed that katB was transcribed as an approximately 1.6-kb monocistronic mRNA. The ...

  • Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa 

    Wade, Dana S.; Calfee, M. Worth; Rocha, Edson R.; Ling, Elizabeth A.; Engstrom, Elana; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2005-07)
    Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using ...

  • Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases 

    Yeung, Fan; Ramsey, Catherine S.; Popko-Scibor, Anita E.; Allison, David F.; Gray, Lisa G.; Shin, Min; Kumar, Manish; Li, Duo; McCubrey, James A.; Mayo, Marty W. (2014-02)
    Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, ...

  • Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1 

    Dyson, Ossie F.; Walker, Lia R.; Whitehouse, Adrian; Cook, Paul P.; Akula, Shaw M. (2012)
    Article Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Media ...

  • Review: Carbon Nanotubes and Chronic Granulomatous Disease 

    Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary Jane (2014-06-23)
    Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ...

  • Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis 

    Betteken, Michael I. (East Carolina University, 2015-12-02)
    Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ...