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Control of vascular smooth muscle cell growth by connexin 43
(2012-06-21)
Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ...
Damage control surgery: It's evolution over the last 20 years
(2012-03-15)
In less than twenty years, what began as a concept for the treatment of exsanguinating truncal trauma patients has become the primary treatment model for numerous emergent, life threatening surgical conditions incapable ...
Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
(2012-01-04)
Polybrominated diphenyl ethers (PBDEs) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. Toxicity of these compounds has become a concern because detectable levels of PBDEs ...
Informational Odds Ratio: A Useful Measure of Epidemiologic Association in Environment Exposure Studies
(2012-04)
The informational odds ratio (IOR) measures the post-exposure odds divided by the pre-exposure odds (ie, information gained after knowing exposure status). A desirable property of an adjusted ratio estimate is collapsibility ...
Introducing the global medical community to the information presented at local scientific conferences through nephrology blogs
(2012-12-14)
An increasing number of healthcare providers author medical blogs (bloggers) to educate the public and fellow physicians. Traditionally, many bloggers have assumed that readers are most interested in information presented ...
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
(2012-10-16)
Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure that ...
Inhibition of vascular smooth muscle growth via signaling crosstalk between amp-activated protein kinase and camp-dependent protein kinase
(2012-10-29)
Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ...
Effects of ectopic expression of NGAL on doxorubicin sensitivity
(2012-10-20)
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ...
Harnessing the PI3K/Akt/mtor pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels
(2012-08-09)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant hematological disorder arising in the thymus from T-cell progenitors. T-ALL mainly affects children and young adults, and remains fatal in 20% of ...