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TLR5 participates in the TLR4 receptor complex and promotes MyD88- dependent signaling in environmental lung injury
(2020-01-28)
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to ...
Understanding Racial Disparities in Exposure to Traffic-Related Air Pollution: Considering the Spatiotemporal Dynamics of Population Distribution
(2020-02-01)
This study investigates the effect of spatiotemporal distributions of racial groups on
disparities in exposure to traffic-related air pollution by considering people’s daily movement
patterns. Due to human mobility, a ...
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
(2020-02-21)
be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ...
A Bayesian machine scientist to aid in the solution of challenging scientific problems
(2020-01-31)
Closed-form, interpretable mathematical models have been instrumental for advancing our understanding of the world; with the data revolution, we may now be in a position to uncover new such models for many systems from ...
Engaging with Library Staff: Lessons from a Staff Assembly
(2020-06-17)
East Carolina University’s J.Y. Joyner Library provides its employees with the opportunity to have their voice heard and impact the direction of the library by engaging its staff assemblies. The current SHRA Executive ...
Developing Concept Enriched Models for Big Data Processing Within the Medical Domain
(2020-07)
Within the past few years, the medical domain has endeavored to incorporate artificial intelligence, including cognitive computing tools, to develop enriched models for processing and synthesizing knowledge from Big Data. ...
Exploring sustainability of affordability initiatives: a library case study
(2020-09)
Purpose
The cost of textbooks continues to rise for college students along with the cost of tuition. These costs can impact student success. In response to the rising costs, higher education institutions have started ...
HOW CAN WE REDUCE THE EFFECTS OF ENVIRONMENTAL POLLUTANTS ON THE PLACENTA?
(East Carolina University, 2020-11-19)
Prenatal exposure to endocrine disrupting chemicals can lead to birth defects and adult disease. While it is impossible to avoid pollutant exposure, development of a prenatal supplement that augments natural protective ...
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
(2020-01-24)
PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation.
Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by
interacting with PUF binding element (PBE) in the 30 untranslated ...