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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
(2017-02)
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development
(2017-01-23)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether ...
Rho GTPases as therapeutic targets in Alzheimer’s disease
(2017-12-15)
The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated as critical ...
Seasonal home range dynamics and sex dierences in habitat use in a threatened, coastal marsh bird
(2017-02)
A comprehensive understanding of spatiotemporal ecology is needed to develop con- servation strategies for declining species. The king rail (Rallus elegans) is a secretive marsh bird whose range historically extended across ...
Simulating and quantifying legacy topographic data uncertainty: an initial step to advancing topographic change analyses
(2017-10)
Rapid technological advances, sustained funding, and a greater recognition of the value of topographic data have helped develop an increasing archive of topographic data sources. Advances in basic and applied research ...
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
(2017-02-21)
Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy
in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the ...
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
(2017-12-21)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry.
We recently demonstrated ...
Potential Mechanisms and Functions of Intermittent Neural Synchronization
(2017-05-30)
Neural synchronization is believed to play an important role in different brain functions. Synchrony in cortical and subcortical circuits is frequently variable in time and not perfect. Few long intervals of desynchronized ...
Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus
(2017-01-03)
Since the introduction of West Nile virus (WNV) into North America in 1999 a number of pas- serine bird species have been found to play a role in the amplification of the virus. Arbovirus surveillance, observational studies ...
Stable optical trapping and sensitive characterization of nanostructures using standing- wave Raman tweezers
(2017-02-17)
Optical manipulation and label-free characterization of nanoscale structures open up new possibilities for assembly and control of nanodevices and biomolecules. Optical tweezers integrated with Raman spectroscopy allows ...