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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
(2017-02)
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development
(2017-01-23)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether ...
Rho GTPases as therapeutic targets in Alzheimer’s disease
(2017-12-15)
The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated as critical ...
Seasonal home range dynamics and sex dierences in habitat use in a threatened, coastal marsh bird
(2017-02)
A comprehensive understanding of spatiotemporal ecology is needed to develop con- servation strategies for declining species. The king rail (Rallus elegans) is a secretive marsh bird whose range historically extended across ...
Simulating and quantifying legacy topographic data uncertainty: an initial step to advancing topographic change analyses
(2017-10)
Rapid technological advances, sustained funding, and a greater recognition of the value of topographic data have helped develop an increasing archive of topographic data sources. Advances in basic and applied research ...
Oral microbe-host interactions: influence of β-glucans on gene expression of inflammatory cytokines and metabolome profile
(2017-03-07)
Background: The aim of this study was to evaluate the effects of β-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber ...
Nearshore mixing and nutrient delivery along the western Antarctic Peninsula
(2017-10)
The surface waters of the Southern Ocean play a key role in the global climate and carbon cycles by
promoting growth of some of the world’s largest phytoplankton blooms. Several studies have emphasized the
importance of ...
Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones
(2017-01)
Context.—Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because ...
Una adelfa en tierras extrañas emblemática y misoginia en la "Comedia famosa de los guanches de Tenerife y conquista de Canaria
(2017)
In his play Los guanches de Tenerife Lope de Vega resorts to one of the emblems included in his friend Hernando de Soto’s Emblemas moralizadas (1599) to dramatize the encounter between Guanches and Spaniards and to represent ...
Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study
(2017-12-19)
Background: Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type
2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ...