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An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study
(2017-03-21)
A novel and versatile “bottom-up” approach is developed to estimate the radiobiological effect of clinic
radiotherapy. The model consists of multi-scale Monte Carlo simulations from organ to cell levels. At cellular level, ...
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
(2017-08-24)
Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to
cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ...
Author Impact Metrics in Communication Sciences and Disorder Research
(2017-09)
Purpose: The purpose was to examine author-level impact metrics for faculty in the communication sciences and disorder research field across a variety of databases.
Method: Author-level impact metrics were collected for ...
Changes in zooplankton community, and seston and zooplankton fatty acid profiles at the freshwater/saltwater interface of the Chowan River, North Carolina
(2017-08-16)
The variability in zooplankton fatty acid composition may be an indicator of larval fish habitat quality as fatty acids are linked to fish larval growth and survival. We sampled an anadromous fish nursery, the Chowan River, ...
Bevacizumab in the treatment of NSCLC: patient selection and perspectives
(2017-12-14)
Non-small-cell lung cancer (NSCLC) represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 ...
Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
(2017-10)
Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that ...
Clinical assessment of medical students in the Emergency Department, A National Consensus Conference
(2017-01)
BACKGROUND
The clinical assessment of medical students in the emergency department (ED) is a highly variable process in which clerkship directors (CD) create and use institution-specific tools, many with unproven reliability ...
Beyond Beck's triad: A case report of cardiac tamponade in a “super-super” obese patient
(2017-06)
Cardiac tamponade is a medical emergency with various etiologies. Prompt recognition of the signs and symptoms of cardiac tamponade is critical but potentially full of challenge in clinical practice [1]. Here we report a ...
EphrinA1-Fc attenuates myocardial ischemia/ reperfusion injury in mice
(2017-12-13)
EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy car- diomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection ...
Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy
(2017-10-12)
In this study, functional near-infrared spectroscopy (fNIRS) was used to record brain activa- tion during cognitive testing in older individuals (88±6yo; N = 19) living in residential care communities. This population, ...