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The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
(2018-02-26)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins ...
The National Clinical Assessment Tool for Medical Students in the Emergency Department (NCAT-EM)
(2018-01)
Introduction: Clinical assessment of medical students in emergency medicine (EM) clerkships is
a highly variable process that presents unique challenges and opportunities. Currently, clerkship directors use institution-specific ...
The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
(2018-06-03)
Background. Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial. Methods. Patients with nonmetastatic IBC between ...
The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids
(2018-11-06)
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduc- tion and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been described for ...
The state of the science of nurse work environments in the United States: A systematic review
(2018-04-16)
A healthy nurse work environment is a workplace that is safe, empowering, and satisfying. Many research studies were conducted on nurse work environments in the last decade; however, it lacks an overview of these research ...
The best of both worlds? A review of delayed selfing in flowering plants
(2018-04-06)
PREMISE OF STUDY: In a seminal body of theory, Lloyd showed that the fitness consequences of selfing will depend on its timing in anthesis. Selfing that occurs after opportunities for outcrossing or pollen dispersal can ...
Claudin‑7 modulates cell‑matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells
(2018-12-31)
Claudins are a family of tight junction proteins, and serve important roles in epithelial barrier, selective ion transports and cancer metastasis. Although the exact role of claudin-7 in human lung cancer has not been ...
β-catenin nuclear translocation induced by HIF-1α overexpression leads to the radioresistance of prostate cancer
(2018-03-16)
Hypoxia-inducible factor-1α (HIF-1α) is known to play crucial roles in tumor radioresistance; however, the molecular mechanisms responsible for the promotion of tumor radioresistance by HIF-1α remain unclear. β-catenin is ...
The effects of emotional states and traits on time perception
(2018-08-20)
Background: Models of time perception share an element of scalar expectancy theory known as the internal clock, containing specific mechanisms by which the brain is able to experience time passing and function effectively. ...
Strongly interacting matter under rotation
(2018-02-02)
The vorticity-driven effects are systematically studied in various aspects. With AMPT the distributions of vorticity has been investigated in heavy ion collisions with different collision parameters. Taking the rotational ...