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Spontaneous bile duct perforation in a neonate
(2018-08-14)
We present a case of spontaneous biliary perforation (SBP) in a previously healthy 3-week-old boy with wor- sening scleral icterus, abdominal distension, and acholic stools. Abdominal ultrasound demonstrated moderate ascites ...
Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-series
(2018-12-16)
Background
With the advent of immune-checkpoint inhibitors and targeted treatments (TT), there have been unprecedented response rates and survival in advanced melanoma, but the optimal sequencing of these two treatments ...
Venous varices of the heart: a case report of spontaneous coronary sinus thrombosis with persistent left superior vena cava
(2018-08-16)
Absence of coronary sinus (CS) ostium and presence of a persistent superior left vena cava (PLSVC) are rare congenital anomalies.1 We report a case of spontaneous CS thrombosis with PLSVC associated with new-onset atrial ...
Multilevel Structural Equation Modeling of Students’ Dietary Intentions/Behaviors, BMI, and the Healthfulness of Convenience Stores
(2018-10-23)
When dietary behaviors are habitual, intentions are low, and environmental cues, such as the consumer food environment, might guide behavior. How might intentions to eat healthily and ultimately actual dietary behaviors, ...
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
(2018-07-27)
The mRNA modification N6-methyladenosine (m6A) is involved in many post- transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ...
Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
(2018-11-27)
Background: Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, ...
MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?
(2018-03-31)
The protein MucR from Brucella spp. is involved in the expression regulation of genes necessary for host interaction and infection. MucR is a member of the Ros/MucR family, which comprises prokaryotic zinc-finger proteins ...
Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience
(2018-02)
Age is the greatest risk factor for chronic disease and is associated with a marked decline in functional capacity and quality of life. A key factor contributing to loss of function in older adults is the decline in skeletal ...
NOTCH3 Expression Is Linked to Breast Cancer Seeding and Distant Metastasis
(2018-09-04)
Background: Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. ...
Nevada desert dust with heavy metals suppresses IgM antibody production
(2018-02-09)
Systemic health effects from exposure to a complex natural dust containing heavy metals from the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following ...