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Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome
(2018-05-31)
Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 dia- betes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabet- ics) that underwent RYGB surgery and seven ...
Claudin‑7 modulates cell‑matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells
(2018-12-31)
Claudins are a family of tight junction proteins, and serve important roles in epithelial barrier, selective ion transports and cancer metastasis. Although the exact role of claudin-7 in human lung cancer has not been ...
TEAM-UP for quality: a cluster randomized controlled trial protocol focused on preventing pressure ulcers through repositioning frequency and precipitating factors
(2018-02-20)
Background: Pressure ulcers/injuries (PrUs), a critical concern for nursing homes (NH), are responsible for chronic wounds, amputations, septic infections, and premature deaths. PrUs occur most commonly in older adults and ...
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development
(2018-10-10)
The transition of rod precursor cells to post-mitotic rod photoreceptors can be promoted by extrinsic factors such as insulin-like growth factor 1 (IGF- 1), which regulates phosphatidylinositide concentration, and consequently ...
Temperature Influences Herbivory and Algal Biomass in the Galápagos Islands
(2018-08-17)
Temperature can influence trophic interactions via predictable effects on the metabolism of ecothermic consumers. Under some conditions, warming should increase top–down control, and trophic transfer rates, leading to ...
The Continuing Fellowship Conundrum
(2018-02-11)
The debate for a fair, equitable, and reasonable pathology fellowship application and selection process has been an ongoing issue with ebb and flow over approximately the past 10 years. The authors of this commentary have ...
Temporal dynamics of genetic clines of invasive European green crab (Carcinus maenas) in eastern North America
(2018-06-08)
Two genetically distinct lineages of European green crabs (Carcinus maenas) were in- dependently introduced to eastern North America, the first in the early 19th century and the second in the late 20th century. These ...
The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
(2018-06-03)
Background. Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial. Methods. Patients with nonmetastatic IBC between ...
Cutaneous melanoma: From pathogenesis to therapy (Review)
(2018-02-27)
In less than 10 years, melanoma treatment has been
revolutionized with the approval of tyrosine kinase inhibitors
and immune checkpoint inhibitors, which have been shown
to have a significant impact on the prognosis of ...
COMT Inhibition Alters Cue-Evoked Oscillatory Dynamics during Alcohol Drinking in the Rat
(2018-10-12)
Alterations in the corticostriatal system have been implicated in numerous substance use disorders, including
alcohol use disorder (AUD). Adaptations in this neural system are associated with enhanced drug-seeking
behaviors ...