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N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
(2018-07-27)
The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ...
Emerging role of immune checkpoint blockade in pancreatic cancer
(2018-11-07)
Immune checkpoint blockade (ICB) with programmed cell death protein-1(PD-1)/programmed death ligand -1(PD-L1) antibodies has revolutionized the management of several cancers, especially non-small cell lung cancer, melanoma, ...
TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
(2018-11-28)
Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) estimates that more than 29 million people in the ...
Angioedema after thrombolysis with tissue plasminogen activator: An airway emergency.
(2019-01-19)
Recombinant tissue plasminogen activator (rtPA), an enzyme that catalyzes the conversion of plasminogen to plasmin resulting in fibrinolysis, is used for the treatment of acute ischemic strokes. The use of this medication ...
Profile of Public Health Leadership
(2018-09)
Sustainability Attitudes of College Students as Future Business Leaders
(East Carolina University, 2018-05-03)
Limited time and finite resources are motivating firms to make significant changes in policy and business practices to maintain profits, sustain the environment, and further a companies’ strategic goals. Managers now value ...
Outer Banks Tourists' Preferences, Sensitivities, and Environmental Perceptions: A Case Study of Cape Hatteras National Seashore
(East Carolina University, 2018-07-17)
Tourism is the driving economic force for North Carolina's Outer Banks, attracting millions of visitors every year. However, through the combined effects of increased human activity and development, storms, sea level rise, ...