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Gene Regulatory Evolution During Speciation in a Songbird
(2016-03-10)
Over the last decade, tremendous progress has been made toward a comparative un- derstanding of gene regulatory evolution. However, we know little about how gene regulation evolves in birds, and how divergent genomes ...
An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders
(2016-12-30)
Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of ...
Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice
(2016-02-19)
Loss of strength in human and animal models of aging can be partially attributed to a well-recognized decrease in muscle mass; however, starting at middle-age, the normalized force (force/ muscle cross-sectional area) in ...
Coastal barrier stratigraphy for Holocene high-resolution sea-level reconstruction
(2016-12-08)
The uncertainties surrounding present and future sea-level rise have revived the debate around sea-level changes through the deglaciation and mid- to late Holocene, from which arises a need for high-quality reconstructions ...
CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway
(2016-03-29)
Distant metastasis remains the major failure of nasopharyngeal carcinoma (NPC). In this study, the roles of chemokine C-C motif ligand 2 (CCL2), and its receptor chemokine C-C motif receptor type 2 (CCR2) on NPC metastasis ...
Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion
(2016-07-08)
Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following ...
Clinical and echocardiographic predictors of mortality in acute pulmonary embolism
(2016-10-28)
Purpose: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism ...
Chinese Americans’ Views and Use of Family Health History: A Qualitative Study
(2016-09-20)
Objective
Family health history (FHH) plays a significant role in early disease detection and preven- tion. Although Asian Americans are the fastest growing U.S. immigrant group, no data exists regarding Chinese Americans’ ...
Case report of atypical Still's disease: a diagnosis of exclusion
(2016)
Introduction: We present an unusual presentation of a 39-year-old man with myalgias and shortness of breath.
Chief complaints: The patient presented to the emergency department with complaints of myalgias, shortness of ...
Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein–Protein Interactions
(2016-02-22)
Protein–protein interactions (PPIs) have widely acknowledged roles in the regulation of development, but few studies have addressed the timing and mechanism of shifting PPIs over evolutionary history. The B-class MADS-box ...