Browsing Health Sciences Campus by Title
Now showing items 41-60 of 2643
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Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
(2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ... -
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
(2014-10)The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a ... -
Acute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarization
(2010-07)Background The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. Objective We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 ... -
ACUTE CARE NURSES’ KNOWLEDGE ON IN-HOSPITAL STROKES AND PREDICTORS OF KNOWLEDGE
(East Carolina University, 2023-04-21)In-hospital strokes (IHS) account for one in five strokes; however, IHS patients have higher mortality and are half as likely to be discharged home when compared to community-occurring strokes (Chen et al., 2018). Nurse-driven ... -
Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study
(2011-03)Background: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood. Objectives: We examined the effects and time course of exposure to fine ... -
Adaptations of Pseudomonas aeruginosa to the Cystic Fibrosis Lung Environment Can Include Deregulation of zwf, Encoding Glucose-6-Phosphate Dehydrogenase
(East Carolina University, 2005-11)Cystic fibrosis (CF) patients are highly susceptible to chronic pulmonary disease caused by mucoid Pseudomonas aeruginosa strains that overproduce the exopolysaccharide alginate. We showed here that a mutation in zwf, ... -
Addressing COVID-19 Vaccine Hesitancy Using a Vaccine Decision Aid Tool
(2022-07-21)The COVID-19 pandemic highlighted health disparities among minority racial groups causing higher COVID-19 morbidity and mortality rates. Once the COVID-19 vaccine became available, Black/African American people had low ... -
Addressing Nurse Practitioner Role Transition During Doctor of Nursing Practice Education
(2023-07-13)Role transition is a known, multifactorial challenge new graduate advanced practice registered nurses (APRNs) face during their transition into practice causing reduced self-confidence, hindered role development, ... -
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ... -
Administrative Changes to Decrease Patient Absenteeism: A Quality Improvement Project
(2019-11-22)Patient no-shows are individuals who fail to attend outpatient medical appointments without notification. This detrimental behavior leads to poor health outcomes, decrease in access to care, and financial losses. A ...