Browsing Brody School of Medicine by Title
Now showing items 1184-1203 of 1484
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The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis
(East Carolina University, 2000-09)The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ... -
Reducing Neurocognitive Impairment In Treating Limited Stage Small Cell Lung Cancer with Gamma Knife Radiosurgery
(2023-07-31)Small Cell Lung Cancer (SCLC) represents 15% of lung cancer and is characterized by rapid growth with metastasis resulting in poor survival rates.1 SCLC with a limited stage defined as disease limited to the hemithorax ... -
Regulation of KSHV replication by glycoprotein B: chronicles of a virus and its host
(East Carolina University, 2011)Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of three cancers: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic form of multicentric Castleman disease (MCD), shares many ... -
The regulation of anthranilate synthesis for the production of pqs in pseudomonas aeruginosa
(East Carolina University, 2013)The ubiquitous bacterium P. aeruginosa is an important human pathogen that causes devastating infections in immunocompromised patients and chronic infections in cystic fibrosis patients. The ability of P. aeruginosa to ... -
Regulation of Bacteriodes fragilis katB mRNA by oxidative stress and carbon limitation.
(East Carolina University, 1997-11)Regulation of the katB catalase gene in the anaerobic bacterium Bacteroides fragilis was studied. Northern blot hybridization analyses revealed that katB was transcribed as an approximately 1.6-kb monocistronic mRNA. The ... -
Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumour necrosis factor.
(East Carolina University, 1988-02-01)Tumour necrosis factor (TNF) was previously shown to suppress lipoprotein lipase (LPL) synthesis and activity in 3T3-L1 adipocytes. The present study examined the effect ofTNF on amounts ofmRNA for LPL in 3T3-Ll cells. ... -
Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa
(East Carolina University, 2005-07)Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using ... -
Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases
(2014-02)Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, ... -
Regulation of Transglutaminase 2 structure and function by Ca²⁺ and [alpha]-synuclein
(East Carolina University, 2016-07-14)Transglutaminase 2 (TG2) catalyzes the Ca2+-dependent transamidation of protein substrates between glutamine and lysine residues by formation of an N[epsilon]-([gamma]-L-glutamyl)-L-lysine isopeptide bond. The Ca2+-dependent ... -
Relationship Between Cardiovascular Disease Risk and Fast Food Consumption in Undergraduate Honors College Students
(2014)College students are often pushed towards fast foods as a means of getting a pleasurable, quick bite to eat. Fast foods are high in fat, salt, and sugar content and can lead to cardiovascular disease(CVD) risk. Honors ... -
Relationship of N-glycans to Neuronal Dysfunction
(East Carolina University, 2019-06-07)N-glycosylation is important in regulating protein activity and serves several vital roles contributing to protein folding, protein assembly, stability, and interactions. Changes in branching of N-glycans are linked to ... -
Religious fasting poses challenges and benefits
(2022-02-23)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is about learning the challenges and benefits religious fasting may or may not have on one's health. -
Reporting and Concordance of Methodologic Criteria Between Abstracts and Articles in Diagnostic Test Studies
(East Carolina University, 2000-03)OBJECTIVE: To evaluate the quality and concordance of methodologic criteria in abstracts versus articles regarding the diagnosis of trichomoniasis. STUDY DESIGN: Survey of published literature. DATA SOURCES: ...