Browsing Brody School of Medicine by Title
Now showing items 1231-1250 of 1484
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Robotic Surgical Training in an Academic Institution
(East Carolina University, 2001-10)Objective To detail robotic procedure development and clinical applications for mitral valve, biliary, and gastric reflux operations, and to implement a multispecialty robotic surgery training curriculum for both ... -
Robotics in Cardiac Surgery: Past, Present, and Future
(2013-07)Robotic cardiac operations evolved from minimally invasive operations and offer similar theoretical benefits, including less pain, shorter length of stay, improved cosmesis, and quicker return to preoperative level of ... -
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ... -
Role of Barium Swallow in Diagnosing Clinically Significant Anastomotic Leak following Esophagectomy
(2016-04)Background Barium swallow is performed following esophagectomy to evaluate the anastomosis for detection of leaks and to assess the emptying of the gastric conduit. The aim of this study was to evaluate the reliability ... -
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic neurosecretory centers. nNOS gene deletion ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis
(East Carolina University, 2015-12-02)Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
(2014-03)Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ... -
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
(2011-03)Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ...