Browsing Brody School of Medicine by Title
Now showing items 1287-1306 of 1484
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Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
(East Carolina University, 2008-11-03)The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ... -
Smart injection syringe systems providing real-time user feedback of correct needle position
(2009-02-09)Syringe assemblies include a syringe with a syringe body (15b) defining a fluid cavity in fluid communication with an injection needle (25); a force, pressure and/or flow sensor (30) in fluid communication with the needle; ... -
Smoking and dietary inadequacy among Inuvialuit women of child bearing age in the Northwest Territories, Canada
(2013)Objective The prevalence of smoking in Aboriginal Canadians is higher than non-Aboriginal Canadians, a behavior that also tends to alter dietary patterns. Compared with the general Canadian population, maternal smoking ... -
A Soft Spot
(2022-03-17) -
Software for objective comparison of vocal acoustic features over weeks of audio recording: KLFromRecordingDays
(2017-10-09)KLFromRecordingDays allows measurement of Kullback–Leibler (KL) distances between 2D probability distributions of vocal acoustic features. Greater KL distance measures reflect increased phonological divergence across the ... -
Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant
(East Carolina University, 2005-02)Pseudomonas aeruginosa is a gram-negative bacterium that causes serious infections in immunocompromised individuals and cystic fibrosis patients. This opportunistic pathogen controls many of its virulence factors and ... -
Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ... -
Sometimes I Think I am Losing my MIND
(2022-03-23)These slides were presented to learners through ECU's Lifelong Learning Program in Spring 2022. They provide an overview of the foods and beverages in our diets that may be hurting or helping our memory - including a review ... -
Special Concerns through an early pregnancy journey
(2016-06)Nutrition and supplementation in the woman of reproductive age can have profound and lasting effects on her child’s health. Preconception planning for all women should include advice to begin folic acid supplementation at ... -
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
(2000-03-21)A DNA comprises an oligonucleotide antisense to mRNA encoding an adenosine A.sub.1 or A.sub.3 receptor. The oligo is provided as a composition, various formulations, a capsule, and cartridge and in the form of a kit. The ... -
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
(East Carolina University, 2021-05-04)Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ... -
Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling
(2013)Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ... -
Spontaneous Weight Change during Chronic Hepatitis C Treatment: Association with Virologic Response Rates
(2013)Objective: We examined weight changes during chronic hepatitis C (CHC) therapy and association with virologic response. Methods: Weight changes were compared between subjects achieving rapid, early, and sustained virologic ...